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c/sideeffects·posted 3 months ago by u/mass_spec_maggie

constipation: the version I wish someone had shown me in week 1

Side Effects Clean Column ×2 Long Haul ×1 The Quiet One ×1

constipation: the version I wish someone had shown me in week 1. Same spreadsheet I have been keeping since the start, nothing retrofitted.

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 62 probably does not, and that is worth saying to a clinician rather than to us.

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

Not medical advice, obviously, and nothing here is approved for human use. One person with a spreadsheet.

3,070 up / 78 down98% upvoted44 commentsid 1cf71t12 Apr 2026

44 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/nausea_notesMOD729 points·3 months ago

Left up. It is a description of one person’s week and it is flagged as such.

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u/laila_delgado173 points·3 months ago

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

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u/yannick_barros0 points·3 months ago

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

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u/ferritin_low265 points·3 months ago

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

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u/mass_spec_maggieOPMS136 points·3 months ago·edited

How long has it been going on for now?

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u/usp_appendixcompendial186 points·3 months ago·edited

I would be careful here. "Everyone gets this" is not true, and it makes the people who get something unusual assume they are fine when they should be asking.

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u/leila_silva65 points·3 months ago

Not convinced by that mechanism. Slowed gastric emptying explains fullness and reflux; it does not explain what you are describing.

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u/vendorinvestigate_vic51 points·3 months ago

sulphur burps are unpleasant and they are not dangerous

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u/ayesha_radich60 points·3 months ago·edited

sulphur burps are unpleasant and they are not dangerous

Disagreeing with this one line: that symptom is not on the wait-and-see list and should not be posted as though it is.

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u/ferran_krastev17 points·3 months ago

That reads like advice, and none of us can give it. Describe what you did, not what somebody else should do.

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u/rania_diallo-31 points·3 months ago

hair shedding follows the weight loss, not the drug, and it stops

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u/rania_marchand1 point·3 months ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/emil_barros1 point·3 months ago

reflux at night, try not eating in the three hours before bed

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u/diego_sorensen114 points·3 months ago

Disagree. Severe abdominal pain is not on the list of things to wait out, and this board should not be treating it as one.

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u/marta_marchand31 points·3 months ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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u/neha_rahimi9 points·3 months ago

reflux on day two and gone by day four is the standard shape

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u/sanne_laurent4 points·3 months ago

write down when it starts and stops, the pattern is the useful part

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u/liv_vukovic4 points·3 months ago·edited

fibre and water before you buy anything to fix it

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u/sena_teixeira47 points·3 months ago

the food noise going quiet is the effect people came for, and sulphur burps are the toll for the first fortnight

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u/liv_vukovic37 points·3 months ago

fatigue plus low intake is usually just low intake

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u/hassan_ostergaard35 points·3 months ago

Kept a one-line-a-day log for two months. The pattern was obvious on paper and invisible in my head.

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u/cesar_oyelaran10 points·3 months ago

smaller meals, earlier, is the boring advice that works

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u/iman_falk2 points·3 months ago

Held the dose for an extra six weeks instead of stepping. The injection-site soreness settled and I lost the same amount anyway.

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Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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