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going up faster doesn’t get you there faster, it just gets you sicker faster
Learned this one the expensive way. Went up because the scale stalled, not because I actually needed to, and all I bought myself was two rough weeks and no extra loss…
Tirzepatide
c/tirzepatide · created 9 Aug 2023
Dual GIP/GLP-1 agonism. Mounjaro, Zepbound, compounded and research tirzepatide.
Hot
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the actual arithmetic for splitting a weekly mg total into two draws, worked example
Getting DMs asking to show the math instead of just saying "split it evenly" so here's a full worked example using round numbers. Say a vial is labelled 10mg and…
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posted 4 days ago by u/nightowl_injector
[Log] eight weeks in, here’s the actual schedule and what each step felt likePosting the boring version of a titration log because I wish I'd had one with this much unremarkable detail before I started. Weeks 1–4: starter dose, mild fatigue day…
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posted 4 days ago by u/devils_advocate_d
is the "week 4 wall" a real physiological thing or just when people start actually weighing themselves properlyGenuine discussion question, not trying to be contrarian for its own sake this time. Is there an actual physiological reason weeks 4-ish tend to stall, or is it mostly…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards367
posted 5 days ago by u/customs_seizure_sid
is the tirz appetite thing actually different or am i imagining itis the tirz appetite thing actually different or am i imagining it. If this has been answered properly somewhere, link me and I will delete. Switching from semaglutide,…
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posted 5 days ago by u/elin_varga
[Results] 5mg for eight months, never went higher, -22kg5mg for eight months, never went higher, -22kg. Posting the boring middle of the process, because the internet is full of the start and the end and nothing else.…
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posted 7 days ago by u/emil_okwuosa
why is nobody talking about the SURPASS-CVOT readoutAsking properly rather than in a comment on somebody else’s thread: why is nobody talking about the SURPASS-CVOT readout. Vials and pens carry the same molecule; what…
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posted 6 days ago by u/marta_dziedzic
[Lab] SSA tirz 10mg — Janoshik 99.1%, third batch in a rowSSA tirz 10mg — Janoshik 99.1%, third batch in a row, and before anyone asks: same batch throughout, single submission, no cherry-picking between services. 10mg and…
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posted 10 days ago by u/kaia_cabrera
[Discussion] "tirz is stronger than sema" needs a comparator dose or it means nothing"tirz is stronger than sema" needs a comparator dose or it means nothing. Making the case below, and I expect to lose some of it in the comments. Came off sema and onto…
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posted 11 days ago by u/ferran_mensah
GIP agonism explained like i am five, pleaseGIP agonism explained like i am five, please — a position I have arrived at slowly and would like tested. Vials and pens carry the same molecule; what differs is fill…
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posted 13 days ago by u/hana_pereira
the nausea profile at 7.5 was worse than 10 for me and i cannot explain itthe nausea profile at 7.5 was worse than 10 for me and i cannot explain it. It is the sort of thing everyone half-believes and nobody writes down. Appetite effect for…
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posted 15 days ago by u/elin_varga
[Titration] 12 weeks per step is not too slow, it is just unfashionableThe title is the argument: 12 weeks per step is not too slow, it is just unfashionable. Here is the rest of it. Pulling the figures out of the title: 12 weeks. All of…
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posted 17 days ago by u/titration_marshal
SURMOUNT-1 was -20.9% at 72 weeks. that is the number, not -30%Right: SURMOUNT-1 was -20.9% at 72 weeks. that is the number, not -30%. I paid for this one myself, nobody sent me anything, and the receipts are in the comments. Hard…
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posted 19 days ago by u/discount_math_dm
anyone else find 15mg genuinely unpleasant with no extra lossAsking properly rather than in a comment on somebody else’s thread: anyone else find 15mg genuinely unpleasant with no extra loss. Figures up front so nobody has to…
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posted 21 days ago by u/laila_wikstrom
[Trial Data] SURMOUNT-4 withdrawal arm is the scariest chart in this spaceSURMOUNT-4 withdrawal arm is the scariest chart in this space. It is the sort of thing everyone half-believes and nobody writes down. Weekly dosing again, half-life in…
Janoshik Analytical — independent HPLC & mass spec
Send the vial, get the number. Third-party purity and identity testing, results published to you regardless of what they say.
Test a vialSponsoredGL Biochem (Shanghai) Ltd. — the synthesis house
Est. 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. There is a fair chance the vial you are about to send for testing started here. Batch-specific COA as standard.
glbiochem.net2.9k
posted 24 days ago by u/cormac_pereira
compounded tirz pricing has doubled in my area in four monthsThe title is the argument: compounded tirz pricing has doubled in my area in four months. Here is the rest of it. The distribution matters more than the mean. In the…
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posted 26 days ago by u/dario_vermeulen
my resting HR went from 58 to 66 on titration and settled backmy resting HR went from 58 to 66 on titration and settled back. Not a hot take, just something I have not seen said plainly here. Held 7.5 for five months. Everyone…
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posted 28 days ago by u/nordic_pricing
[Question] does the vial concentration change how much dead space costs meQuestion in the title, detail here: does the vial concentration change how much dead space costs me. The distribution matters more than the mean. In the trial…
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posted 1 months ago by u/hana_pereira
the Zepbound question that gets asked weekly, answered properlythe Zepbound question that gets asked weekly, answered properly, and I am aware this is a minority view on this board. Sulphur burps for the first eight days after each…
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posted 1 months ago by u/slow_logbook_ftw
[Results] 65 weeks on 15mg, full numbers, ask me anything boringCheck-in as promised in the title: 65 weeks on 15mg, full numbers, ask me anything boring. The relevant figures are 65 weeks and 15mg, and they come from the same log I…
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posted 1 months ago by u/adnan_nascimento
dual agonist — my 18-week log, condensed into one tableSomething I keep coming back to: dual agonist — my 18-week log, condensed into one table. SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change.…
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posted 1 months ago by u/kaia_wojcik
[Discussion] we are measuring tirzepatide at the wrong time and calling it noisewe are measuring tirzepatide at the wrong time and calling it noise. Change my mind, genuinely — I have no stake in being right about this. Went 10 to 12.5 on the…
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posted 1 months ago by u/search_before_post
am I the only one who found Mounjaro harder than the injectionsThe title is the whole question — am I the only one who found Mounjaro harder than the injections — but here is why I am asking. The thing nobody warned me about was…
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posted 1 months ago by u/taper_off_tabitha
[Lab] split one vial across PeptideMeter and VendorInvestigate — 98.4% and 97.2%Posting this because the title is the whole finding — split one vial across PeptideMeter and VendorInvestigate — 98.4% and 97.2% — and a number without its method is a…
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posted 1 months ago by u/cato_girard
why does nobody talk about SURPASSSlightly embarrassed to be asking this, but: why does nobody talk about SURPASS. Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed…