[Discussion] we are measuring tirzepatide at the wrong time and calling it noise
we are measuring tirzepatide at the wrong time and calling it noise. Change my mind, genuinely — I have no stake in being right about this.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
Tell me where this is wrong. That is the useful part of posting it.
best — the order this archive was captured in
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
Not sure that follows. You went up a step and changed your training in the same fortnight.
Not sure that follows.
Saving this one. It is the clearest statement of the stall problem I have read here.
Not sure that follows.
This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.
the reflux profile is genuinely gentler than people expect coming from sema
the reflux profile is genuinely gentler than people expect coming from sema
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.
Careful with "everyone tolerates it better".
santiago_villalobos is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.
2.5 is the starter dose and it is not meant to be the dose that works
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.
Pen or vial? The step sizes available differ and it changes this answer.
Pen or vial?
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
Correction to my own post above — I said 10mg and I have been on 12.5mg since the spring. Same argument, wrong number.
sulphur burps are the signature complaint and they are not dangerous
What step are you on and how long have you been there?
Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
if 7.5 is working, 10 is not automatically better
- 1Not sure that follows. You went up a step and changed your training in the…11 comments in this branch · started by u/certified_reference
- 2Pen or vial? The step sizes available differ and it changes this answer.6 comments in this branch · started by u/zaid_balogun