[Discussion] we are measuring GIP at the wrong time and calling it noise
Posting this as a discussion rather than a claim: we are measuring GIP at the wrong time and calling it noise.
16kg over 37 weeks, never went past 10mg, and constipation stayed mild the whole way. Posting because the loud threads are all 15mg.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
Please do not ask me what dose you should be on. I genuinely do not know and neither does anyone else here.
best — the order this archive was captured in
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your food noise pattern is a guess.
Pen or vial? The step sizes available differ and it changes this answer.
Week 94 was the first time the scale moved after a five-week stall. I changed nothing in that window.
The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 62 is not a fair reading.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
dual agonist, so the GIP arm is doing something the sema threads will not tell you about
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
That percentage is body weight change, not body fat.
Saving this one. It is the clearest statement of the stall problem I have read here.
pens and vials are the same molecule, the price is the difference
This matches mine. Milder injection-site soreness than I expected, and what there was settled inside a fortnight of each step.
hold the dose that works, the ladder is not a leaderboard
zepbound and mounjaro are the same compound with different labels
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
Correction to my own post above — I said 5mg and I have been on 5mg since the spring. Same argument, wrong number.
switching from sema is not a dose conversion, there is no clean equivalence