[Trial Data] SURMOUNT-4 withdrawal arm is the scariest chart in this space
SURMOUNT-4 withdrawal arm is the scariest chart in this space. It is the sort of thing everyone half-believes and nobody writes down.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.
best — the order this archive was captured in
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
hold the dose that works, the ladder is not a leaderboard
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
switching from sema is not a dose conversion, there is no clean equivalence
Same experience with the appetite effect being flatter across the week rather than front-loaded.
sulphur burps are the signature complaint and they are not dangerous
sulphur burps are the signature complaint and they are not dangerous
gentle_correction is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.
Correction to my own post above — I said 12.5mg and I have been on 10mg since the spring. Same argument, wrong number.
dual agonist, so the GIP arm is doing something the sema threads will not tell you about
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
Saving this one. It is the clearest statement of the stall problem I have read here.
Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.
- 1Vials and pens carry the same molecule; what differs is fill volume, device…6 comments in this branch · started by u/nz_unfunded