[Question] does the vial concentration change how much dead space costs me
Question in the title, detail here: does the vial concentration change how much dead space costs me.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
Screenshot none of this. Read the whole thread, including the parts where I am told I am wrong.
best — the order this archive was captured in
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.
This matches mine. Milder muscle cramps than I expected, and what there was settled inside a fortnight of each step.
What is the waist doing? That is usually the number still moving during a scale stall.
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
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22kg over 53 weeks, never went past 10mg, and food noise stayed mild the whole way. Posting because the loud threads are all 15mg.
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
Research-use-only material is not approved for human use.
Saving this one. It is the clearest statement of the stall problem I have read here.
dual agonist, so the GIP arm is doing something the sema threads will not tell you about
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 24 is not a fair reading.
2.5 is the starter dose and it is not meant to be the dose that works
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
the injection-site soreness profile is genuinely gentler than people expect coming from sema
SURMOUNT-1 landed around 21% at 72 weeks on the top arm
the trials titrated on a calendar, real people titrate on symptoms
Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.
Are you comparing yourself with the trial mean or with the people who post the most?
This is the fifth "should I go up" post today and they are all welcome — but no member here can answer it for you.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
zepbound and mounjaro are the same compound with different labels
Week 43 was the first time the scale moved after a five-week stall. I changed nothing in that window.
sulphur burps are the signature complaint and they are not dangerous
sulphur burps are the signature complaint and they are not dangerous
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
hold the dose that works, the ladder is not a leaderboard
week 8 is early to draw any conclusion at all
- 1This is the fifth "should I go up" post today and they are all welcome — but…10 comments in this branch · started by u/quiet_moderator
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