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small win: fatigue stopped being a problem at week 82

Side Effects Clean Column ×8 The Quiet One ×1 Cold Box ×1

small win: fatigue stopped being a problem at week 82. Full detail below, and I have tried to keep the editorialising out of it.

Kept a one-line-a-day log for two months. The pattern was obvious on paper and invisible in my head.

Held the dose for an extra six weeks instead of stepping. The food noise settled and I lost the same amount anyway.

Happy to answer the boring questions. Those are usually the ones worth asking.

10,214 up / 512 down95% upvoted65 commentsid l7n9tv21 Jan 2024

65 comments

27 in this archive, depth 4

best — the order this archive was captured in

u/ferran_krastev915 points·2 years ago

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

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u/janoshik_junkieindependent tester294 points·2 years ago

Pushback: you changed the dose, the meal timing and the training in the same fortnight, so the attribution is guesswork.

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u/britt_abubakar305 points·2 years ago

Has anything else changed in the same window?

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[removed]117 points·2 years ago

[removed by moderator]

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u/blunt_coldbox_202482 points·2 years ago

Not convinced by that mechanism. Slowed gastric emptying explains fullness and reflux; it does not explain what you are describing.

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u/ilias_cabrera235 points·2 years ago

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

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u/mass_spec_maggieMS835 points·2 years ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

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u/bastian_eriksen674 points·2 years ago

Same pattern here. It settled at a stable dose without me doing anything clever.

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u/laila_delgado617 points·2 years ago

muscle cramps for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

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u/nausea_notesMOD426 points·2 years ago

Flair set to Question. Also the standing reminder that nothing on this board is medical advice.

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u/vendorinvestigate_vicOP238 points·2 years ago

Correction: that is a known effect of reduced intake rather than a direct drug effect. The distinction matters because the fix is different.

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u/vendorinvestigate_vicOP109 points·2 years ago

Correcting my own comment above: I said day three and my log says day two. Same pattern, wrong day.

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u/aurel_mwangi311 points·2 years ago

Yes — the day-two-to-day-four window is so consistent across this board that it is almost diagnostic.

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u/cesar_oyelaran195 points·2 years ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/enzo_danquah67 points·2 years ago·edited

That symptom is not the one being described upthread.

Agreed, with the caveat that "usually settles" is not "always settles" and the exceptions should still get asked about properly.

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u/elin_lindqvist79 points·2 years ago

reflux at night, try not eating in the three hours before bed

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u/cormac_danquah164 points·2 years ago

write down when it starts and stops, the pattern is the useful part

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u/tomas_lehtinen122 points·2 years ago·edited

write down when it starts and stops, the pattern is the useful part

Disagreeing with this one line: that symptom is not on the wait-and-see list and should not be posted as though it is.

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u/rohan_steiner37 points·2 years ago

I would be careful here. "Everyone gets this" is not true, and it makes the people who get something unusual assume they are fine when they should be asking.

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u/chidi_abubakar94 points·2 years ago

Which day of the week relative to the shot does it hit?

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u/leila_silva43 points·2 years ago

Severe, or unpleasant? They are genuinely different questions and the answers diverge.

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u/blunt_coldbox_2024303 points·2 years ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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u/rekha_mbeki254 points·2 years ago

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

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u/liv_okafor212 points·2 years ago

a rough fortnight at each step is normal, a rough three months is not

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u/britt_abubakar89 points·2 years ago

That reads like advice, and none of us can give it. Describe what you did, not what somebody else should do.

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u/ayesha_erdogan-7 points·2 years ago

fatigue plus low intake is usually just low intake

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u/quiet_moderatormod114 points·2 years ago·edited

Are you eating in the couple of hours before you sleep?

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