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c/sideeffects·posted 1 months ago by u/fibre_forward

the gallbladder question that gets asked weekly, answered properly

Question Long Haul ×4 Slow Clap ×3

Thinking out loud about this: the gallbladder question that gets asked weekly, answered properly.

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

fatigue for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

Ask me anything specific. Anything general I will probably get wrong.

1,954 up / 105 down95% upvoted33 commentsid 1938o019 Jun 2026

33 comments

30 in this archive, depth 6

best — the order this archive was captured in

u/fabio_nkemelu0 points·1 months ago

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

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[removed]1 point·1 months ago

[removed by moderator]

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u/fabio_nkemelu-19 points·1 months ago

holding a dose an extra month is a legitimate answer to bad tolerance

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u/neha_rahimi274 points·1 months ago·edited

Is it every week or did it start at a particular dose?

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u/gentle_correctionMOD122 points·1 months ago

Left up. It is a description of one person’s week and it is flagged as such.

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u/fibre_forwardOP205 points·1 months ago

nobody warns you about how much of this is timing rather than dose

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u/sena_teixeira50 points·1 months ago

Reflux was the one that got me. Stopped eating in the three hours before bed and it went from nightly to almost never.

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u/fibre_forwardOP39 points·1 months ago

eating slower does more than most of the supplements people recommend

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u/diego_sorensen73 points·1 months ago

write down when it starts and stops, the pattern is the useful part

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u/zeynep_zielinski0 points·1 months ago

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

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u/aurel_mwangi1 point·1 months ago·edited

Agreed. Slowing down at meals did more for my sulphur burps than everything I bought to fix it, which was embarrassing to discover.

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u/salma_baptista1 point·1 months ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 32 probably does not, and that is worth saying to a clinician rather than to us.

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u/chidi_abubakar1 point·1 months ago

Careful with the supplement recommendation. There is no evidence for it here and the mechanism you are proposing does not hold.

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u/tomas_lehtinen1 point·1 months ago·edited

A symptom that begins the day after the shot and fades by day four tracks the exposure curve.

Disagreeing with this one line: that symptom is not on the wait-and-see list and should not be posted as though it is.

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u/adaeze_batista1 point·1 months ago

Nobody warned me about constipation and I would have liked the warning. It was not dangerous, it was just deeply unpleasant and completely unexpected.

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u/rania_marchand190 points·1 months ago

if it is severe or persistent that is a clinician question, not a board question

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u/blunt_coldbox_202478 points·1 months ago

This. A bad fortnight after a step is expected. A bad quarter is a reason to talk to somebody who knows your history.

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u/janoshik_junkieindependent tester19 points·1 months ago

Held the dose for an extra six weeks instead of stepping. The early fullness settled and I lost the same amount anyway.

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u/cormac_danquah28 points·1 months ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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u/fibre_forwardOP20 points·1 months ago

constipation on day two and gone by day four is the standard shape

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u/zeynep_zielinski59 points·1 months ago

reflux at night, try not eating in the three hours before bed

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u/idris_iyer132 points·1 months ago

Not convinced by that mechanism. Slowed gastric emptying explains fullness and reflux; it does not explain what you are describing.

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u/zeynep_ndiaye73 points·1 months ago

How long after a step up did this start?

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u/karma_irrelevant55 points·1 months ago

Has anything else changed in the same window?

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u/tomas_broberg80 points·1 months ago

Kept a one-line-a-day log for two months. The pattern was obvious on paper and invisible in my head.

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u/hassan_castellanos41 points·1 months ago

Mine settled at week 69 and has not come back since, across two more steps.

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u/vendorinvestigate_vic50 points·1 months ago

a rough fortnight at each step is normal, a rough three months is not

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u/blank_injection42 points·1 months ago

Cosigning the fibre and water answer. Unglamorous, free, and it fixed it for me inside a week.

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u/saskia_lokken17 points·1 months ago

Disagree. Severe abdominal pain is not on the list of things to wait out, and this board should not be treating it as one.

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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