week 40 check-in — 14kg down, sulphur burps manageable, one thing confusing me
Reporting in. week 40 check-in — 14kg down, sulphur burps manageable, one thing confusing me.
The relevant figures are week 40 and 14kg, and they come from the same log I have kept the whole time.
The fatigue profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression.
Stopped at a low step because there was no reason to go further and no data to tell me what further would do.
If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.
best — the order this archive was captured in
It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel component and it is the one with the least human outcome data behind it.
the TRIUMPH programme is still running, so anything definitive is premature
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the energy-expenditure story is mechanistically interesting and clinically unproven
Disagree. "More receptors means more effect" is not how any of this works and the trial data does not support the linear story.
Sceptical of the extrapolation. Forty-eight weeks does not tell you about seventy-two, and the curve shape is exactly what is unknown.
Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish.
Glucagon receptor agonism is associated with increased energy expenditure and with hepatic effects. That is a mechanistic story with strong preclinical support and limited phase 2 human data.
phase 2 data only, and people quote it like it is a label
Sent a vial to PeptideMeter out of curiosity. Result was 98.3% against a claimed 97.5%, which is the first independent number I had seen for this compound anywhere.
Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.
Agreed on the heart-rate reports. They are consistent enough across the threads to be worth noting, not enough to be a finding.
- 1It is a triple agonist at the GLP-1, GIP and glucagon receptors. The…6 comments in this branch · started by u/nikhil_lindqvist
- 2Increases in heart rate have been reported across this receptor class. The…6 comments in this branch · started by u/cagrilintide_enthusiast