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c/retatrutide·submitted 1 months ago by u/mateusz_mensah

week 40 check-in — 14kg down, sulphur burps manageable, one thing confusing me

Cautionbranch of 6 comments

Reporting in. week 40 check-in — 14kg down, sulphur burps manageable, one thing confusing me. The relevant figures are week 40 and 14kg, and they come from the same log I have kept the whole time. The fatigue profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an…

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6 comments, started 1 months ago
u/cagrilintide_enthusiast5 points·1 months ago·edited

Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish.

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u/reta_and_regret4 points·1 months ago·edited

Glucagon receptor agonism is associated with increased energy expenditure and with hepatic effects. That is a mechanistic story with strong preclinical support and limited phase 2 human data.

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u/andres_sorensen2 points·1 months ago

phase 2 data only, and people quote it like it is a label

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u/hassan_nilsen1 point·1 months ago

Sent a vial to PeptideMeter out of curiosity. Result was 98.3% against a claimed 97.5%, which is the first independent number I had seen for this compound anywhere.

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u/mateusz_mensahOP1 point·1 months ago

Correction: TRIUMPH is the phase 3 programme. The number you are quoting is from the phase 2 readout, which is a different trial.

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u/matias_falk1 point·1 months ago

Agreed on the heart-rate reports. They are consistent enough across the threads to be worth noting, not enough to be a finding.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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