c/retatrutide · created 6 Sep 2023
Triple agonist. Phase 3 data, research-grade material, and a lot of unknowns.
Jastreboff et al., N Engl J Med , 2023. Phase 2. Forty-eight weeks. Mean change −24.2% in the highest dose arm. Every one of those qualifiers gets dropped when the…
reta phase 2 was -24.2% at 48 weeks and people quote it like it is a maintenance number. That is the headline. The document, the batch and the service are below so you…
went too fast on reta and my resting HR told me before i noticed. Change my mind, genuinely — I have no stake in being right about this. Read the phase 2 paper twice…
Posting this as a discussion rather than a claim: this is not approved anywhere and half this community forgets that. What the glucagon arm is doing, as best anyone can…
Vendor-level purity averages over time, built from independent results rather than vendor claims. Transparent methodology, open dataset.
Browse resultstwo reta batches, two services, 98.4% and 97.9%, and before anyone asks: same batch throughout, single submission, no cherry-picking between services. 98.4% and 97.9%.…
the glucagon arm is why the appetite effect feels different — a position I have arrived at slowly and would like tested. Watched heart rate on a wearable across twelve…
TRIUMPH timeline — what we actually know vs what gets repeated. Change my mind, genuinely — I have no stake in being right about this. Nothing containing this compound…
The title is the whole question — is anyone tracking heart rate properly on reta or are we all guessing — but here is why I am asking. Independent purity testing on…
dose-response looked steeper than anything else in the class and that cuts both ways, and I am aware this is a minority view on this board. Increases in heart rate have…
Something I keep coming back to: reta made me not want food OR water and that is its own problem. The early fullness profile felt different rather than worse. Hard to…
Genuine question, and the title is the question: why is reta purity testing so much more variable between labs. The constipation profile felt different rather than…
came off reta after 14 weeks. here is the honest version. Not a hot take, just something I have not seen said plainly here. The relevant figures are 14 weeks, and they…
"just start at 2mg" is the worst advice in this community, which sounds obvious until you try to state the evidence for it. Pulling the figures out of the title: 2mg.…
the retatrutide question that gets asked weekly, answered properly. It is the sort of thing everyone half-believes and nobody writes down. Went up slowly, deliberately,…
the dose escalation question that gets asked weekly, answered properly. Making the case below, and I expect to lose some of it in the comments. Stopped at a low step…
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standardsRight: split one vial across Janoshik and Medutest — 99.2% and 98.9%. I paid for this one myself, nobody sent me anything, and the receipts are in the comments. Hard…
is it normal to get muscle cramps at week 85. Same spreadsheet I have been keeping since the start, nothing retrofitted. Phase 2 estimates effect and finds a dose…
glucagon is doing more work than we give it credit for. It is the sort of thing everyone half-believes and nobody writes down. Glucagon receptor agonism is associated…
Posting this as a discussion rather than a claim: the TRIUMPH advice in here is 2 years out of date. Figures up front so nobody has to dig: 2 years. Sent a vial to…
Reporting in. anyone else notice retatrutide kicking in around week 83. Nothing containing this compound is approved anywhere. Research-use-only material is not…
Reporting in. week 40 check-in — 14kg down, sulphur burps manageable, one thing confusing me. The relevant figures are week 40 and 14kg, and they come from the same log…
Putting this to the board: proposal — a flair for glucagon posts. What the glucagon arm is doing, as best anyone can say from public data. GLP-1 and GIP agonism cover…
three years of retatrutide threads, summarised so you do not have to read them. It is the sort of thing everyone half-believes and nobody writes down. Glucagon receptor…
retatrutide is the most under-discussed thing on this board — a position I have arrived at slowly and would like tested. Phase 2 estimates effect and finds a dose…
small win: dose escalation stopped being a problem at week 55, logged the same way every week so the comparison is at least internally fair. Increases in heart rate…
Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.
Certified reference materials for peptide identity and purity work.
sigmaaldrich.comSeveral compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.
Reference