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c/retatrutide·posted 9 days ago by u/source_or_silence

reta made me not want food OR water and that is its own problem

Question

Something I keep coming back to: reta made me not want food OR water and that is its own problem.

The early fullness profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an impression.

Watched heart rate on a wearable across twelve weeks because the threads said to. It moved a little and I have no idea whether that means anything.

Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use, and that is a statement of fact rather than a disclaimer.

Sceptical readings welcome. The confident ones are the ones I distrust.

241 up / 268 down47% upvoted5 commentsid 1mkuzz20 Jul 2026

5 comments

5 in this archive, depth 2

best — the order this archive was captured in

u/freya_baptista6 points·9 days ago

Increases in heart rate have been reported across this receptor class. The magnitude and clinical significance are exactly what phase 3 is powered to establish.

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u/solene_ilunga4 points·9 days ago

Yes — the comparison threads are apples to oranges and they generate more heat than anything else here.

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u/careful_gradient322 points·9 days ago

Went up slowly, deliberately, because everything on this board says the escalation is where trouble lives. Uneventful so far and I am not going to pretend that is a finding.

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u/iman_castellanos4 points·9 days ago

Stopped at a low step because there was no reason to go further and no data to tell me what further would do.

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u/naomi_erdogan3 points·8 days ago

comparing reta phase 2 to sema phase 3 is comparing different things

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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