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c/retatrutide·posted 2 years ago by u/divya_bakken

10 months in and dose escalation is still the thing I get wrong

Trial Data Long Haul ×8 Cold Box ×3 Slow Clap ×1

Check-in as promised in the title: 10 months in and dose escalation is still the thing I get wrong.

10 months. Those are measured, not estimated, and not rounded up in my favour.

Kept a log specifically because there is so little published. It is one person and it is not data.

The thing that surprised me was how much of the discussion here is inference rather than measurement.

That is everything I have. The rest is opinion and I have tried to keep it out.

25,596 up / 9,795 down72% upvoted40 commentsid 1ahtny6 Dec 2023

40 comments

3 in this archive, depth 2

best — the order this archive was captured in

u/nabila_bakken2.8k points·2 years ago

Phase 2 estimates effect and finds a dose range. Phase 3 estimates it precisely in a bigger population and catches what phase 2 was too small to see. Treating them as the same tier of evidence is the recurring error here.

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u/incretin_ivyMOD2.3k points·2 years ago

Standing reminder in every thread here: unapproved compound, research material is not for human use, nothing on this board is medical advice.

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u/sena_teixeira1.4k points·2 years ago

This. The phase 2 result was genuinely large and it was also 48 weeks in a few hundred people.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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