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c/retatrutide·submitted 1 months ago by u/mateusz_mensah

week 40 check-in — 14kg down, sulphur burps manageable, one thing confusing me

Cautionbranch of 6 comments

Reporting in. week 40 check-in — 14kg down, sulphur burps manageable, one thing confusing me. The relevant figures are week 40 and 14kg, and they come from the same log I have kept the whole time. The fatigue profile felt different rather than worse. Hard to describe and impossible to quantify, so take it as an…

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6 comments, started 1 months ago
u/nikhil_lindqvist8 points·1 months ago

It is a triple agonist at the GLP-1, GIP and glucagon receptors. The glucagon arm is the genuinely novel component and it is the one with the least human outcome data behind it.

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u/source_or_silence2 points·1 months ago

the TRIUMPH programme is still running, so anything definitive is premature

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[removed]1 point·1 months ago

[removed by moderator]

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u/careful_gradient_notes1 point·1 months ago

the energy-expenditure story is mechanistically interesting and clinically unproven

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u/endotoxin_elliemicro1 point·1 months ago

Disagree. "More receptors means more effect" is not how any of this works and the trial data does not support the linear story.

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u/aa_analysis_andy1 point·1 months ago

Sceptical of the extrapolation. Forty-eight weeks does not tell you about seventy-two, and the curve shape is exactly what is unknown.

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Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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