220
[Question] how do you actually verify incretin
how do you actually verify incretin. I am not trying to be the "source?" guy. I would just like a source. Glucose-dependent insulin secretion is why hypoglycaemia risk…
incretin
Every GLP Research Hub submission tagged to incretin, ranked by score. Discussed in 1 community.
Communities covering this
217
[PSA] receptor is not what most of this community thinks it is
receptor is not what most of this community thinks it is — with the reasoning, because a rule without a reason gets ignored. The GIP question, which is the most…
189
the mechanism question that gets asked weekly, answered properly
the mechanism question that gets asked weekly, answered properly. Change my mind, genuinely — I have no stake in being right about this. Tried to build a mental model…
178
[Discussion] appetite is doing more work than we give it credit for
Something I keep coming back to: appetite is doing more work than we give it credit for. Asked a question here that I thought was stupid and got three papers back. Best…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards160
help me understand appetite, I have read the wiki twice
Trying to get a straight answer on this: help me understand appetite, I have read the wiki twice. Why mechanism talk keeps misleading people, including me. A mechanism…
155
unpopular opinion: most of what gets said here about gastric emptying is guesswork
unpopular opinion: most of what gets said here about gastric emptying is guesswork. Making the case below, and I expect to lose some of it in the comments. Spent an…
153
[Question] gastric emptying — what am I missing here
gastric emptying — what am I missing here. I would rather ask a basic question now than get this wrong quietly for two months. Started reading limitations sections…
149
three years of pharmacology threads, summarised so you do not have to read them
Something I keep coming back to: three years of pharmacology threads, summarised so you do not have to read them. Long half-life in this class comes from structural…
93
[Explainer] delayed gastric emptying does most of the work people credit to the brain
delayed gastric emptying does most of the work people credit to the brain. If you already knew this, the post is not for you and you can scroll on. Started reading…
80
half-life is 168 hours. that is why your injection day barely matters.
The title is the argument: half-life is 168 hours. that is why your injection day barely matters. Here is the rest of it. Numbers, in the order they matter: 168 hours.…
73
[Question] incretin — what am I missing here
incretin — what am I missing here. I am not trying to be the "source?" guy. I would just like a source. Was completely wrong about the gastric emptying story in a…
40
[Speculation] is the food-noise effect central, peripheral, or both
Trying to get a straight answer on this: is the food-noise effect central, peripheral, or both. The half-life explanation was the thing that made weekly dosing…
0
[Explainer] steady state at 4–5 weeks, and what that means for your titration
Short public-service post: steady state at 4–5 weeks, and what that means for your titration. Hard numbers: 5 weeks. Anything softer than that is flagged as an…
0
someone explain gastric emptying to me like I have not read a paper in years
Trying to get a straight answer on this: someone explain gastric emptying to me like I have not read a paper in years. Why mechanism talk keeps misleading people,…
0
[Question] how do you actually verify receptor
how do you actually verify receptor. I would rather ask a basic question now than get this wrong quietly for two months. Started reading limitations sections first. It…
Janoshik Analytical — independent HPLC & mass spec
Send the vial, get the number. Third-party purity and identity testing, results published to you regardless of what they say.
Test a vialSponsoredGL Biochem (Shanghai) Ltd. — the synthesis house
Est. 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. There is a fair chance the vial you are about to send for testing started here. Batch-specific COA as standard.
glbiochem.net0
why does nobody talk about gastric emptying
Trying to get a straight answer on this: why does nobody talk about gastric emptying. The half-life explanation was the thing that made weekly dosing intuitive for me…
0
appetite — 15 things I got wrong before I got it right
Thinking out loud about this: appetite — 15 things I got wrong before I got it right. The GIP question, which is the most interesting unsettled thing in this field.…
0
how much of what we believe about pharmacology actually comes from appetite threads
how much of what we believe about pharmacology actually comes from appetite threads. I would rather ask a basic question now than get this wrong quietly for two months.…
-14
[Discussion] why did splitting/microdosing culture even take off here given the total lack of trial data
Not attacking anyone doing it, genuinely curious about the social/informational dynamic. There's essentially zero published outcome data for splitting or…
-95
the gastric emptying thing finally clicked for me and I want to write it down
the gastric emptying thing finally clicked for me and I want to write it down. Change my mind, genuinely — I have no stake in being right about this. Tried to build a…