[Question] how do you actually verify receptor
how do you actually verify receptor. I would rather ask a basic question now than get this wrong quietly for two months.
Started reading limitations sections first. It has changed how much weight I give to almost everything posted here.
Asked a question here that I thought was stupid and got three papers back. Best thread I have been in on this site.
The mental model, in four steps, that makes the rest of this site legible.
One: gut hormones amplify the insulin response to food. Two: agonists at those receptors act peripherally on insulin secretion and gastric emptying, and centrally on appetite. Three: structural modification gives them a long half-life, so exposure is smooth and weekly. Four: tolerance develops to some effects and not to others.
From those four, most of what the experience boards report falls out: why the side effects cluster early, why they settle at a stable dose, why appetite reduction persists, and why the scale and the appetite move on different clocks.
Tell me where this is wrong. That is the useful part of posting it.
best — the order this archive was captured in
Receptor expression in a tissue is necessary but not sufficient for an effect. You also need the agonist to reach it at relevant exposure, and that is where a lot of confident mechanism talk falls down.
Receptor expression in a tissue is necessary but not sufficient for an effect.
Adding the caveat the paper itself makes in its limitations section, which is stronger than anything in this thread.
What was the exposure in that experiment relative to therapeutic?
half-life is why these are weekly and not daily
Asked for a citation rather than removing. On this board a claim without one is an invitation, not an offence.
Was completely wrong about the gastric emptying story in a thread here two years ago. Someone corrected me with a citation and I have not made that mistake since.