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c/glp1science·posted 1 year ago by u/noor_hovland

why does nobody talk about gastric emptying

Speculation Clean Column ×1

Trying to get a straight answer on this: why does nobody talk about gastric emptying.

The half-life explanation was the thing that made weekly dosing intuitive for me rather than arbitrary.

Was completely wrong about the gastric emptying story in a thread here two years ago. Someone corrected me with a citation and I have not made that mistake since.

Spent an evening on the receptor distribution literature and the side-effect map suddenly stopped looking random.

Would rather be corrected in public than confident in private.

0 up / 0 down43% upvoted7 commentsid 1rwfga24 May 2025

7 comments

7 in this archive, depth 4

best — the order this archive was captured in

u/tomas_broberg2 points·1 year ago

Long half-life in this class comes from structural modification that promotes albumin binding and resists enzymatic degradation. Weekly dosing is a consequence of the molecule, not a convenience decision.

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u/noor_hovlandOP3 points·1 year ago

Asked a question here that I thought was stupid and got three papers back. Best thread I have been in on this site.

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u/split_dose_sceptic1 point·1 year ago

Disagree. That is a preclinical finding in a rodent model and you are stating it as human pharmacology.

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u/farid_kuipers1 point·1 year ago

half-life is why these are weekly and not daily

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[removed]1 point·1 year ago

[removed by moderator]

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u/runa_cabrera4 points·1 year ago

the peripheral and central stories are not in competition

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u/aksel_palacios1 point·1 year ago

Are we talking about receptor affinity or clinical potency?

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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