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c/sideeffects·posted 2 months ago by u/ayesha_erdogan

week 73 check-in — 28kg down, early fullness manageable, one thing confusing me

Management Receipts ×6 Well Actually ×1 Cold Box ×1

week 73 check-in — 28kg down, early fullness manageable, one thing confusing me, and the part I actually want to talk about is at the bottom.

Pulling the figures out of the title: week 73 and 28kg. All of it is written down as it happened rather than reconstructed.

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

Mine settled at week 37 and has not come back since, across two more steps.

If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.

4,469 up / 1,615 down73% upvoted56 commentsid 1a7a8a21 May 2026

56 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/diego_sorensen380 points·2 months ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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u/halima_mbeki250 points·2 months ago

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

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u/rekha_mbeki-13 points·2 months ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 90 probably does not, and that is worth saying to a clinician rather than to us.

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u/bastian_eriksen172 points·2 months ago·edited

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

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u/cesar_oyelaran81 points·2 months ago

Right, and the hair thing is worth repeating: it tracks the rate of loss rather than the compound, and it stops.

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u/baseline_drifteranalytical44 points·2 months ago

Correction: that is a known effect of reduced intake rather than a direct drug effect. The distinction matters because the fix is different.

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u/iman_castellanos15 points·2 months ago

reflux at night, try not eating in the three hours before bed

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u/long_post_larry21 points·2 months ago

smaller meals, earlier, is the boring advice that works

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u/marit_coelho136 points·2 months ago

This. A bad fortnight after a step is expected. A bad quarter is a reason to talk to somebody who knows your history.

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u/halima_mbeki198 points·2 months ago

Reflux was the one that got me. Stopped eating in the three hours before bed and it went from nightly to almost never.

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u/ahmed_rasmussen138 points·2 months ago

reflux for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

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u/tomas_broberg44 points·2 months ago

sulphur burps are unpleasant and they are not dangerous

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u/isabela_nilsen24 points·2 months ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/slow_logbook_ftw78 points·2 months ago

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

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u/ayesha_erdoganOP92 points·2 months ago

Has anything else changed in the same window?

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u/iman_castellanos32 points·2 months ago

holding a dose an extra month is a legitimate answer to bad tolerance

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u/marit_coelho29 points·2 months ago

early fullness on day two and gone by day four is the standard shape

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u/nausea_notesMOD60 points·2 months ago

This one needs a clinician rather than a comment section, and we have said so in the thread rather than removing it.

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u/ayesha_erdoganOP37 points·2 months ago

write down when it starts and stops, the pattern is the useful part

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u/ayesha_erdoganOP37 points·2 months ago

hair shedding follows the weight loss, not the drug, and it stops

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u/yannick_barros18 points·2 months ago·edited

Agreed. Slowing down at meals did more for my nausea than everything I bought to fix it, which was embarrassing to discover.

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u/fatima_asante11 points·2 months ago

Is it every week or did it start at a particular dose?

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u/ferran_dahlberg44 points·2 months ago

Kept a one-line-a-day log for two months. The pattern was obvious on paper and invisible in my head.

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u/ayesha_radich24 points·2 months ago

Are you eating in the couple of hours before you sleep?

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u/graph_it_gary6 points·2 months ago·edited

Bought four different things to fix my sulphur burps. What actually worked was eating half as fast.

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u/constipation_clubside effects4 points·2 months ago

What is intake actually looking like — fibre and water especially?

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u/brigade_detector1 point·2 months ago

the early fullness that arrives at week 30 out of nowhere is usually something else

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u/adaeze_brandt4 points·2 months ago

Which day of the week relative to the shot does it hit?

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u/rekha_mbeki6 points·2 months ago·edited

Nobody warned me about injection-site soreness and I would have liked the warning. It was not dangerous, it was just deeply unpleasant and completely unexpected.

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u/amara_haddad11 points·2 months ago

Are you eating in the couple of hours before you sleep?

This is the shape almost everybody here describes, and it is the single most reassuring thing in the thread.

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Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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