144
SURPASS — 17 things I got wrong before I got it right
SURPASS — 17 things I got wrong before I got it right, which sounds obvious until you try to state the evidence for it. Discontinuation rates are a tolerability result.…
STEP
Every GLP Research Hub submission tagged to STEP, ranked by score. Discussed in 1 community.
Communities covering this
119
[Discussion] can we stop arguing about TRIUMPH until somebody posts a number
Question in the title, detail here: can we stop arguing about TRIUMPH until somebody posts a number. Intention-to-treat analyses everybody randomised regardless of what…
107
[Discussion] TRIUMPH is doing more work than we give it credit for
The title is the argument: TRIUMPH is doing more work than we give it credit for. Here is the rest of it. Went looking for the registered protocol to see whether the…
95
[Readout] SELECT: MACE HR 0.80, and the absolute numbers people skip
SELECT: MACE HR 0.80, and the absolute numbers people skip — a position I have arrived at slowly and would like tested. Compared myself to a trial mean for about six…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards95
the STEP question that gets asked weekly, answered properly
Something I keep coming back to: the STEP question that gets asked weekly, answered properly. Cardiovascular outcome trials are powered for events, not for weight, and…
94
hazard ratio is the most under-discussed thing on this board
hazard ratio is the most under-discussed thing on this board. Not a hot take, just something I have not seen said plainly here. Spent an evening with the appendix…
79
three years of SURMOUNT threads, summarised so you do not have to read them
Something I keep coming back to: three years of SURMOUNT threads, summarised so you do not have to read them. Cardiovascular outcome trials are powered for events, not…
77
reading SURMOUNT threads from 2024 and half of it aged badly
reading SURMOUNT threads from 2024 and half of it aged badly, and I am aware this is a minority view on this board. Open-label extensions lose their randomisation.…
58
[PSA] STEP is not what most of this community thinks it is
STEP is not what most of this community thinks it is — with the reasoning, because a rule without a reason gets ignored. On means, which this board treats as targets…
-31
three years of SURMOUNT threads, summarised so you do not have to read them
Posting this as a discussion rather than a claim: three years of SURMOUNT threads, summarised so you do not have to read them. Relative risk reduction without the…
-35
[Meta] the FLOW rule is doing its job and people should stop complaining
the FLOW rule is doing its job and people should stop complaining. This affects how posts get sorted and removed, so it belongs in the open. The discontinuation numbers…
-38
help me understand SURMOUNT, I have read the wiki twice
The title is the whole question — help me understand SURMOUNT, I have read the wiki twice — but here is why I am asking. Discontinuation rates are a tolerability…
-47
SURPASS — 10 things I got wrong before I got it right
Thinking out loud about this: SURPASS — 10 things I got wrong before I got it right. Started keeping the trial identifiers straight in a note file because I kept mixing…
-59
FLOW got published and nobody in here is talking about eGFR slope
FLOW (Perkovic et al., N Engl J Med , 2024) reported a hazard ratio of 0.76 for the composite kidney endpoint in people with type 2 diabetes and chronic kidney disease.…