three years of SURMOUNT threads, summarised so you do not have to read them
Something I keep coming back to: three years of SURMOUNT threads, summarised so you do not have to read them.
Cardiovascular outcome trials are powered for events, not for weight, and are typically run in a different population with different inclusion criteria. Reading a weight number out of one is reading a secondary endpoint.
The registered protocol is public. Comparing the registered primary endpoint with the reported one is a two-minute check and it is how outcome switching gets caught.
Relative risk reduction without the baseline rate is uninterpretable. A large relative reduction on a small absolute risk is a small absolute benefit.
If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.
best — the order this archive was captured in
Open-label extensions lose their randomisation. Anybody still enrolled at week 104 is a selected group and the numbers describe that group.
read the endpoint before you read the headline
Spent an evening with the appendix tables and found the subgroup detail that the entire thread had been speculating about.
The press release said that; the publication says something more hedged. Worth reading both.
a mean is not a promise
a mean is not a promise
first_hundred is right about the programme names. They are different populations with different endpoints.
check who the comparator was before you compare anything
discontinuation rate is a result, not a footnote
Retitled: the original quoted a diabetes endpoint as an obesity result.
Retitled: the original quoted a diabetes endpoint as an obesity result.
This is the distinction that would end about half the arguments on this board.
Push back: an open-label extension tells you about the people who stayed. That is a different question.
Quoted a figure here confidently, got asked whether it was ITT, went and checked, and it was not. Learned something.
SELECT was cardiovascular outcomes, not weight
Same. A press release is a claim about a result; the publication is the result.
What did the confidence interval look like?
- 1Spent an evening with the appendix tables and found the subgroup detail that…9 comments in this branch · started by u/yusuf_ramos