c/trialwatch wiki

What this community is for

Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

c/trialwatch was created on 4 Nov 2023 and currently has 33,900 members and 95 captured submissions. It sits in the second tier of the site, which mostly affects how fast a question gets answered rather than how well.

Rules, and why each exists

Community rules come first, then the six site-wide rules that apply everywhere on GLP Research Hub. Community rules are enforced by the moderators listed at the bottom of this page; site rules are enforced by everyone.

1. Press-release-only posts must be flaired Press Release until a publication exists.
2. Give the trial name, phase, n, and primary endpoint in the body.
3. Relative risk reduction alone is not a result. Show the absolute numbers.

And the site rules, which are short on purpose:

1. Independent community. Nobody here sells anything, and anyone who tries is banned.
2. Not medical advice. Describe what you did; never prescribe to a stranger.
3. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
4. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
5. No contact handles, wallet addresses or tracking numbers — they identify people.
6. Be recognisably decent. Disagree hard, insult nobody.

Terms you will see

Vocabulary that turns up constantly in c/trialwatch. Each links to the topic page, which collects every submission that touches it.

• STEP — discussed frequently in this community — see the topic page for every submission that touches it.
• SURMOUNT — discussed frequently in this community — see the topic page for every submission that touches it.
• SURPASS — discussed frequently in this community — see the topic page for every submission that touches it.
• SELECT — discussed frequently in this community — see the topic page for every submission that touches it.
• FLOW — discussed frequently in this community — see the topic page for every submission that touches it.
• TRIUMPH — discussed frequently in this community — see the topic page for every submission that touches it.
• endpoint — discussed frequently in this community — see the topic page for every submission that touches it.
• hazard ratio — discussed frequently in this community — see the topic page for every submission that touches it.

Start here

The twelve highest-scoring submissions in this community. Not necessarily the most correct — the most agreed-with, which is a different thing, and worth remembering when you read them.

1. unpopular opinion: most of what gets said here about hazard ratio is guesswork — 8.2k points, 40 comments, 2 years ago
2. SELECT: what the trials say vs what this community says — 7.4k points, 41 comments, 2 years ago
3. [PSA] write the concentration on the vial. that is the whole post. — 6.7k points, 40 comments, 2 years ago
4. hazard ratio is the most under-discussed thing on this board — 6.4k points, 60 comments, 1 year ago
5. [Meta] proposal — a flair for FLOW posts — 5.7k points, 24 comments, 2 years ago
6. does SELECT actually matter or is it forum lore at this point — 5.7k points, 51 comments, 10 months ago
7. help me understand SURMOUNT, I have read the wiki twice — 4.7k points, 25 comments, 2 years ago
8. does SELECT actually matter or is it forum lore at this point — 4.6k points, 40 comments, 1 year ago
9. genuine question about TRIUMPH that I am slightly embarrassed to ask — 4.6k points, 48 comments, 2 years ago
10. SURPASS — 9 things I got wrong before I got it right — 4.5k points, 42 comments, 2 years ago
11. reading SURMOUNT threads from 2024 and half of it aged badly — 4k points, 42 comments, 2 years ago
12. SURPASS — 11 things I got wrong before I got it right — 3.7k points, 56 comments, 1 year ago

Asked constantly

• [Question] how do you actually verify SURPASS
• [Question] endpoint — what am I missing here
• [Question] how do you actually verify SURPASS
• [Question] how do you actually verify SURPASS
• [Question] how do you actually verify SURPASS

If your question is on that list, read the answers there first. If it is not, ask it — that is what the community is for, and "this has been asked" is only a helpful reply when it comes with a link.

Who runs this

Moderation here is done by volunteers who also post as normal members. They are not clinicians, not vendors, and not paid.

• u/trialwatch_theo — I read the supplementary appendix so you do not have to. Pre-registration or it is a hypothesis.
• u/forest_plot_fiona — Confidence intervals are the entire story. The point estimate is the headline.
• u/hazard_ratio_hal — Relative risk reduction sells papers. Absolute risk reduction makes decisions.
• u/renal_outcomes_r — FLOW changed how I think about eGFR slope. Renal endpoints deserve more airtime.