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c/trialwatch·posted 2 years ago by u/adaeze_weiss

SURPASS — 9 things I got wrong before I got it right

Readout Cold Box ×2 Slow Clap ×3 Receipts ×1

SURPASS — 9 things I got wrong before I got it right. Change my mind, genuinely — I have no stake in being right about this.

Started keeping the trial identifiers straight in a note file because I kept mixing up two programmes in the same sentence.

Quoted a figure here confidently, got asked whether it was ITT, went and checked, and it was not. Learned something.

Read a press release and the publication three months apart. The hedging in the second one was substantial.

Please do not ask me what dose you should be on. I genuinely do not know and neither does anyone else here.

4,920 up / 455 down92% upvoted42 commentsid 44e07s13 May 2024

42 comments

3 in this archive, depth 2

best — the order this archive was captured in

u/annika_fonseca469 points·2 years ago

The registered protocol is public. Comparing the registered primary endpoint with the reported one is a two-minute check and it is how outcome switching gets caught.

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u/naomi_ekstrom377 points·2 years ago

Disagree — that figure is from the diabetes programme and you are quoting it as an obesity endpoint.

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u/hamza_zielinski184 points·2 years ago

Spent an evening with the appendix tables and found the subgroup detail that the entire thread had been speculating about.

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Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

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