STEP

Putting this to the board: the FLOW rule is doing its job and people should stop complaining. Why comparing across trials almost never works, with the specific failure…

SELECT: what the trials say vs what this community says — a position I have arrived at slowly and would like tested. Why comparing across trials almost never works,…

Trying to get a straight answer on this: can we stop arguing about TRIUMPH until somebody posts a number. Compared myself to a trial mean for about six months before…

SURPASS — 14 things I got wrong before I got it right. Making the case below, and I expect to lose some of it in the comments. Quoted a figure here confidently, got…

The title is the argument: SELECT: what the trials say vs what this community says. Here is the rest of it. Intention-to-treat analyses everybody randomised regardless…

how much of what we believe about endpoint actually comes from SELECT threads — that is what I am asking, and I have already read the wiki twice. On means, which this…

SURPASS — 22 things I got wrong before I got it right. Not a hot take, just something I have not seen said plainly here. Spent an evening with the appendix tables and…

Something I keep coming back to: ATTAIN-1 — an oral pill with no food restrictions is a bigger deal than the % suggests. Quoted a figure here confidently, got asked…

proposal — a flair for FLOW posts. Nothing about this affects the ranking maths, before anyone asks. The registered protocol is public. Comparing the registered primary…

Posting this as a discussion rather than a claim: REDEFINE 1 and what CagriSema actually adds over sema alone. Compared myself to a trial mean for about six months…

the FLOW rule is doing its job and people should stop complaining. This affects how posts get sorted and removed, so it belongs in the open. The discontinuation numbers…

Posting this as a discussion rather than a claim: STEP 1 vs SURMOUNT-1 side by side, with the caveats. Compared myself to a trial mean for about six months before…

let the alcohol swab dry before you puncture, that is the step everyone skips, and I say this having got it wrong myself for long enough to be annoyed about it. The…

Genuine question, and the title is the question: how do you actually verify step therapy. Appeal deadlines run from the date on the determination letter. They are…

relative risk reduction sells papers, absolute risk reduction makes decisions. It is the sort of thing everyone half-believes and nobody writes down. The…

Posting this as a discussion rather than a claim: SURPASS — 24 things I got wrong before I got it right. Compared myself to a trial mean for about six months before…

the FLOW rule is doing its job and people should stop complaining. Nothing about this affects the ranking maths, before anyone asks. Started keeping the trial…

new phase 3 numbers, no publication yet, calm down. It is the sort of thing everyone half-believes and nobody writes down. A confidence interval is the range of effects…

the STEP question that gets asked weekly, answered properly. Not a hot take, just something I have not seen said plainly here. Spent an evening with the appendix tables…

STEP is not what most of this community thinks it is — with the reasoning, because a rule without a reason gets ignored. Started keeping the trial identifiers straight…

the STEP thing finally clicked for me and I want to write it down. Not a hot take, just something I have not seen said plainly here. Spent an evening with the appendix…

step therapy is the most under-discussed thing on this board. It is the sort of thing everyone half-believes and nobody writes down. External review was the thing that…

TRIUMPH is doing more work than we give it credit for. It is the sort of thing everyone half-believes and nobody writes down. Spent an evening with the appendix tables…

Slightly embarrassed to be asking this, but: how do you actually verify SURPASS. Argued for a week about a result and then read the limitations section, which conceded…

SURPASS — 16 things I got wrong before I got it right. It is the sort of thing everyone half-believes and nobody writes down. Spent an evening with the appendix tables…