what changed for me between month 6 and month 14
what changed for me between month 6 and month 14. Searched first, found three threads that contradict each other, hence the post. Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule. 24kg over 93 weeks, never went past 10mg, and fatigue stayed mild the whole way.…
Switching from semaglutide, since three people asked in this thread alone.
There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that the first month after a switch is often flat, that the appetite effect feels differently shaped rather than simply stronger, and that starting at the bottom of the ladder again is the common approach.
None of that is a recommendation. It is what the threads say, and the threads are not a clinic.
Are you comparing yourself with the trial mean or with the people who post the most?
the appetite effect is blunter than sema, in a good way, most weeks
Pen or vial? The step sizes available differ and it changes this answer.
Pen or vial?
This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.
This.
thyroid_tangent is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
Came off sema and onto tirz with a two-week gap.
Saving this one. It is the clearest statement of the stall problem I have read here.
2.5 is the starter dose and it is not meant to be the dose that works
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.
Right.
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
zepbound and mounjaro are the same compound with different labels