[Question] how do you actually verify Mounjaro
Asking properly rather than in a comment on somebody else’s thread: how do you actually verify Mounjaro.
On comparing yourself with the trial number.
SURMOUNT-1 reported roughly 21% mean body weight change at 72 weeks on the highest arm. Three things get dropped every time that figure is quoted here. It is a mean, and the distribution around it is very wide. It is 72 weeks, which is a year and a half. And it is a trial population with trial support, which is not the same as a person with a spreadsheet.
Use it as a rough shape, not a benchmark. A 12% year is inside the ordinary range and people quit over it every week on this board.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.
best — the order this archive was captured in
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
The four-week interval in the label is a minimum.
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
Same experience with the appetite effect being flatter across the week rather than front-loaded.
the four-week step schedule is the label, not folklore
Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.
hold the dose that works, the ladder is not a leaderboard
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
pens and vials are the same molecule, the price is the difference
Week 7 was the first time the scale moved after a five-week stall. I changed nothing in that window.
the trials titrated on a calendar, real people titrate on symptoms
dual agonist, so the GIP arm is doing something the sema threads will not tell you about
Left up, flair changed to Discussion.
Saving this one. It is the clearest statement of the stall problem I have read here.
Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.
Does nausea follow the day after the shot, or is it spread across the week?
Yes — 10mg being a genuine landing place for a lot of people is underrated. There is no medal for 15.
the appetite effect is blunter than sema, in a good way, most weeks
Correction to my own post above — I said 5mg and I have been on 7.5mg since the spring. Same argument, wrong number.
Correction to my own post above — I said 5mg and I have been on 7.5mg since the spring.
kaia_cabrera is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.
SURMOUNT-1 landed around 21% at 72 weeks on the top arm
zepbound and mounjaro are the same compound with different labels
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.
I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your food noise pattern is a guess.
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.
Research-use-only material is not approved for human use.
This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.
Not sure that follows. You went up a step and changed your training in the same fortnight.
Are you comparing yourself with the trial mean or with the people who post the most?
- 1Left up, flair changed to Discussion. It is an opinion post and that is fine…9 comments in this branch · started by u/titration_marshal
- 2Does nausea follow the day after the shot, or is it spread across the week?7 comments in this branch · started by u/adnan_nascimento