how much of what we believe about Mounjaro actually comes from Zepbound threads
Asking properly rather than in a comment on somebody else’s thread: how much of what we believe about Mounjaro actually comes from Zepbound threads. On comparing yourself with the trial number. SURMOUNT-1 reported roughly 21% mean body weight change at 72 weeks on the highest arm. Three things get dropped every time…
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
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the trials titrated on a calendar, real people titrate on symptoms
the appetite effect is blunter than sema, in a good way, most weeks
What step are you on and how long have you been there?
Correction to my own post above — I said 15mg and I have been on 2.5mg since the spring. Same argument, wrong number.
Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.
zepbound and mounjaro are the same compound with different labels
switching from sema is not a dose conversion, there is no clean equivalence
pens and vials are the same molecule, the price is the difference
Same experience with the appetite effect being flatter across the week rather than front-loaded.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.