hypoglycaemia: the version I wish someone had shown me in week 1
Reporting in. hypoglycaemia: the version I wish someone had shown me in week 1.
The diabetes and obesity programmes are separate, with different populations and different primary endpoints. Reading a result across from one to the other is not a comparison.
Incretin-based agents stimulate insulin secretion in a glucose-dependent manner, which is why hypoglycaemia risk with them alone is low. Risk rises with agents that act independently of glycaemia.
Happy to answer the boring questions. Those are usually the ones worth asking.
best — the order this archive was captured in
On hypoglycaemia, because the risk gets attributed to the wrong thing constantly.
Incretin-based agents stimulate insulin secretion in a glucose-dependent way: the effect scales with glycaemia rather than acting unconditionally. That is why monotherapy risk is low. Where risk rises substantially is in combination with agents that lower glucose independently of the current level.
Which means the question "does this cause hypos" is not answerable without knowing the rest of the regimen — and that the person who can answer it is the one who wrote the regimen. Nothing on this board is a substitute for that conversation, and the good threads here end by saying so.
CGM shows you the shape, A1c shows you the area
nothing here replaces the person managing your diabetes
Variability dropped before the average did, which was visible on the sensor and invisible on the lab result.
the diabetes trials report different endpoints from the obesity ones
A1c reflects average glycaemia over roughly the preceding three months, weighted towards the most recent weeks. It cannot show variability and it lags any change you make.
A1c, CGM, or fingersticks — which are we discussing?
Agreed on variability. Two people with the same average can have completely different days.
Careful, that is a regimen change suggestion and it needs to come from whoever manages your diabetes.
the fasting number is the one people fixate on and it moves last
A1c is a three-month average and it lags everything
I would not compare your numbers to that population. Different baseline, different regimen, different trial.
- 1A1c reflects average glycaemia over roughly the preceding three months,…8 comments in this branch · started by u/sanne_laurent