my fasting insulin moved and I cannot work out whether metformin is why
my fasting insulin moved and I cannot work out whether metformin is why. It is the sort of thing everyone half-believes and nobody writes down.
Kept fingersticks alongside the sensor for two weeks to sanity-check it. Worth doing once.
My ApoB moved and it turned out to have nothing to do with glucose at all.
Time in range told me far more than the average did. Two quarters with the same A1c looked completely different on the sensor.
Corrections welcome, especially the pedantic ones. Pedantry is how this board earns its reputation.
best — the order this archive was captured in
The order things move in, since nobody explains it and it worries people.
Postprandial excursions generally respond earliest. Variability tends to narrow before the average does, which is visible on a sensor and invisible on a lab result. Fasting glucose is often the laggard, and A1c — being a three-month average — is the last thing to reflect anything.
So a month in which the sensor looks better and the fasting number has not moved is the ordinary sequence, not a contradiction. Knowing that in advance would have saved me a quarter of unnecessary worry, which is why it is worth writing down.
Assumed the weight endpoints from the obesity trials applied to my situation. They are different programmes.
hypoglycaemia risk depends far more on what else you take
Certain conditions affect A1c independently of glycaemia. If a result looks inconsistent with the sensor data, that is a question for whoever manages your care rather than for this board.
check the trial population before quoting a result at somebody
CGM shows you the shape, A1c shows you the area
CGM shows you the shape, A1c shows you the area
This is the distinction that resolves most of the confusion here — average versus shape.
What does time in range look like, not just the average?
Continuous monitoring shows the shape: postprandial excursions, overnight behaviour and time in range. Two people with identical A1c can have very different distributions.
What else is in the regimen?
Disagree — that is an obesity trial endpoint and this thread is about glycaemic control.
Postprandial excursions flattened out first and the fasting number took months to follow. Nobody had told me to expect that order.
Retitled — the original quoted an obesity endpoint as a glycaemic one.
What else is in the regimen?
Disagreeing with this line: that endpoint is from the obesity programme and does not answer the question.