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c/sideeffects·posted 11 months ago by u/naomi_erdogan

what changed for me between month 2 and month 9

Discussion Long Haul ×5 Cold Box ×3

Genuine question, and the title is the question: what changed for me between month 2 and month 9.

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

Screenshot none of this. Read the whole thread, including the parts where I am told I am wrong.

1,880 up / 380 down83% upvoted53 commentsid gsv6cn7 Aug 2025

53 comments

19 in this archive, depth 6

best — the order this archive was captured in

u/aurel_mwangi143 points·11 months ago·edited

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

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u/naomi_erdoganOP92 points·11 months ago

fibre and water before you buy anything to fix it

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u/laila_delgado77 points·11 months ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

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u/naomi_erdoganOP35 points·11 months ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss.

Agreed, with the caveat that "usually settles" is not "always settles" and the exceptions should still get asked about properly.

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u/rafael_ostergaard12 points·11 months ago

muscle cramps on day two and gone by day four is the standard shape

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u/mass_spec_maggieMS-3 points·11 months ago

Keeping a log, and what to put in it.

One line a day: dose, day since injection, what the symptom was and how bad out of five, and roughly what you ate. Two months of that fits on one page and the pattern is obvious on paper in a way it never is in your head.

Mine showed a clean day-two-to-day-four window I had been describing as "random". Once you can see the pattern you can plan around it, and planning around it is most of the relief.

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u/fatima_asante1 point·11 months ago

Keeping a log, and what to put in it.

Adding to this — holding the dose rather than stepping is the option people forget they have.

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u/tomas_broberg44 points·11 months ago

Nobody warned me about reflux and I would have liked the warning. It was not dangerous, it was just deeply unpleasant and completely unexpected.

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u/chidi_demir18 points·11 months ago

Cosigning the fibre and water answer. Unglamorous, free, and it fixed it for me inside a week.

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u/idris_iyer33 points·11 months ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 40 probably does not, and that is worth saying to a clinician rather than to us.

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u/quiet_moderatorMOD22 points·11 months ago

Removed the specific recommendation. Describe your own experience here; do not tell another member what to take or what dose to be on.

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u/naomi_erdoganOP11 points·11 months ago

What is intake actually looking like — fibre and water especially?

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u/quiet_moderatormod5 points·11 months ago

reflux at night, try not eating in the three hours before bed

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u/blunt_coldbox_20242 points·11 months ago

This. A bad fortnight after a step is expected. A bad quarter is a reason to talk to somebody who knows your history.

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u/sequence_checkerresearch peptides1 point·11 months ago·edited

This.

Disagreeing with this one line: that symptom is not on the wait-and-see list and should not be posted as though it is.

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u/lina_dziedzic6 points·11 months ago

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

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u/line_petrov3 points·11 months ago

The fatigue turned out to be that I was eating about a third of what I thought I was.

lina_dziedzic is right about the timing. The day-of-week pattern is the diagnostic bit, not the severity.

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u/reta_and_regret1 point·11 months ago

Kept a one-line-a-day log for two months. The pattern was obvious on paper and invisible in my head.

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u/amara_haddad17 points·11 months ago

Reflux was the one that got me. Stopped eating in the three hours before bed and it went from nightly to almost never.

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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