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c/sideeffects·posted 2 months ago by u/laila_delgado

reflux — 18 things I got wrong before I got it right

Resolved Long Haul ×7 Sourced ×3

reflux — 18 things I got wrong before I got it right, and I am aware this is a minority view on this board.

Bought four different things to fix my nausea. What actually worked was eating half as fast.

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 27 probably does not, and that is worth saying to a clinician rather than to us.

I will update this if the picture changes rather than quietly leaving it up.

2,017 up / 175 down92% upvoted69 commentsid 19xaml16 May 2026

69 comments

30 in this archive, depth 6

best — the order this archive was captured in

u/tomas_lehtinen202 points·2 months ago

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

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u/chidi_abubakar189 points·2 months ago

if it is severe or persistent that is a clinician question, not a board question

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u/tomas_broberg128 points·2 months ago

Mine settled at week 62 and has not come back since, across two more steps.

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u/ahmed_rasmussen33 points·2 months ago·edited

Mine settled at week 62 and has not come back since, across two more steps.

Adding to this — holding the dose rather than stepping is the option people forget they have.

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u/adaeze_brandt8 points·2 months ago

Is it every week or did it start at a particular dose?

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u/karma_irrelevant-10 points·2 months ago

Not convinced by that mechanism. Slowed gastric emptying explains fullness and reflux; it does not explain what you are describing.

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u/diego_sorensen1 point·2 months ago

hair shedding follows the weight loss, not the drug, and it stops

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u/laila_delgadoOP1 point·2 months ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/ahmed_rasmussen1 point·2 months ago

reflux at night, try not eating in the three hours before bed

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u/laila_delgadoOP1 point·2 months ago

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/karma_irrelevant1 point·2 months ago

This. A bad fortnight after a step is expected. A bad quarter is a reason to talk to somebody who knows your history.

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u/leila_silva1 point·2 months ago

nobody warns you about how much of this is timing rather than dose

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u/ferran_krastev1 point·2 months ago

reflux for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

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u/zaid_balogun1 point·2 months ago

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

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[removed]93 points·2 months ago

[removed by moderator]

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u/rania_marchand24 points·2 months ago

smaller meals, earlier, is the boring advice that works

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u/cormac_danquah7 points·2 months ago

sulphur burps are unpleasant and they are not dangerous

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u/laila_delgadoOP5 points·2 months ago

sulphur burps are unpleasant and they are not dangerous

cormac_danquah is right about the timing. The day-of-week pattern is the diagnostic bit, not the severity.

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u/idris_iyer49 points·2 months ago

Correction: that is a known effect of reduced intake rather than a direct drug effect. The distinction matters because the fix is different.

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u/constipation_clubside effects32 points·2 months ago

sulphur burps on day two and gone by day four is the standard shape

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u/elin_trevino53 points·2 months ago

Pushback: you changed the dose, the meal timing and the training in the same fortnight, so the attribution is guesswork.

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u/idris_iyer24 points·2 months ago·edited

Pushback: you changed the dose, the meal timing and the training in the same fortnight, so the attribution is guesswork.

Disagreeing with this one line: that symptom is not on the wait-and-see list and should not be posted as though it is.

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u/rania_marchand44 points·2 months ago

eating slower does more than most of the supplements people recommend

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u/elin_lundgren10 points·2 months ago

the food noise going quiet is the effect people came for, and early fullness is the toll for the first fortnight

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u/rafael_ostergaard4 points·2 months ago

Yes — the day-two-to-day-four window is so consistent across this board that it is almost diagnostic.

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u/line_petrov4 points·2 months ago·edited

the food noise going quiet is the effect people came for, and early fullness is the toll for the first fortnight

This is the shape almost everybody here describes, and it is the single most reassuring thing in the thread.

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u/constipation_clubside effects2 points·2 months ago

Agreed on writing it down. I could not see the pattern until I had six weeks of it on one page.

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u/brigade_detector1 point·2 months ago

Cosigning the fibre and water answer. Unglamorous, free, and it fixed it for me inside a week.

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u/elin_lundgren3 points·2 months ago

Has anything else changed in the same window?

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u/reta_and_regret27 points·2 months ago

What is intake actually looking like — fibre and water especially?

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