[Results] 8 weeks on 7.5mg, full numbers, ask me anything boring
Six-word version is the title — 8 weeks on 7.5mg, full numbers, ask me anything boring — and the rest is context. Hard numbers: 8 weeks and 7.5mg. Anything softer than that is flagged as an impression. The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the…
Same read. The energy-expenditure mechanism is the interesting bit and it is not established in humans at scale.
Cosigning the escalation point. Almost every difficult report on this board is from somebody who went up quickly.
Yes — the comparison threads are apples to oranges and they generate more heat than anything else here.
What do you think the glucagon component is adding, specifically?
This. The phase 2 result was genuinely large and it was also 48 weeks in a few hundred people.
Yes — the comparison threads are apples to oranges and they generate more heat than anything else here.
Adding the standing caveat: none of this is approved anywhere and research material is not for human use.
comparing reta phase 2 to sema phase 3 is comparing different things
Yes — the glucagon arm is what makes it a different proposition rather than a stronger version of the others.