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c/maintenancephase·submitted 1 year ago by u/neha_falk

[Discussion] we are measuring lowest effective dose at the wrong time and calling it noise

Discussionbranch of 6 comments

The title is the argument: we are measuring lowest effective dose at the wrong time and calling it noise. Here is the rest of it. Withdrawal studies in this class consistently show substantial regain after discontinuation. That is a pharmacological finding about a chronic condition, not a statement about anyone’s…

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6 comments, started 1 year ago
u/paloma_stanescu52 points·1 year ago

Dose reduction and interval extension are different interventions. Halving the dose keeps the rhythm and lowers the level; stretching keeps the level and lowers the frequency, with a lower trough.

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u/elise_ramos64 points·1 year ago

the lowest effective dose is a real target and nobody talks about it

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u/copay_card_cc-34 points·1 year ago

Maintenance is the phase with the least published guidance and the most individual variation, which is precisely why board consensus here is worth less than usual.

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u/piotr_grimaldi1 point·1 year ago

maintenance is a phase, not a finish line

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u/santiago_lindqvist1 point·1 year ago

I would not treat a two-kilo range as drift requiring action. That is ordinary weight variation.

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u/purity_pedantanalytical1 point·1 year ago

This. The withdrawal data is not ambiguous and framing regain as a personal failure is both wrong and cruel.

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The part nobody posts about: what happens at goal weight. Finding a lowest effective dose, dose-interval stretching, regain risk data, muscle retention, the psychology of not having a number to chase, and staying on indefinitely versus tapering.

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