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c/glp1women·posted 6 months ago by u/signe_villalobos

small win: PCOS stopped being a problem at week 61

PCOS Receipts ×2 Cold Box ×3

Here it is: small win: PCOS stopped being a problem at week 61. One person, one log, no control group, so read it accordingly.

The one practical change that makes this board’s hardest questions tractable: annotate your log with the cycle.

Hormonal variation affects appetite, fluid and symptom intensity in its own right. Without the annotation, a log shows a dose, a week and a set of symptoms that appear to move at random. With it, patterns that were invisible become obvious in about three months.

Members here who have done it consistently report the same thing: the same dose feels genuinely different at different points, and knowing that in advance converts a confusing fortnight into an expected one. It also makes a much better document to bring to an appointment.

Why the evidence base here is thin, which is not your imagination.

The major trial programmes were designed around endpoints that do not answer most of the questions this board asks: cycle interactions, contraception, fertility, perimenopause. The populations were not enrolled to answer them and the endpoints were not chosen to measure them.

So when you search and find nothing, that is usually the actual state of the literature rather than a failure of searching. What follows practically: be precise about your question, take the pharmacology parts to a pharmacist who can look up product-specific information, and treat confident answers on this board — including the ones that agree with you — with more caution than usual.

Screenshot none of this. Read the whole thread, including the parts where I am told I am wrong.

1,129 up / 194 down85% upvoted51 commentsid 94446212 Jan 2026

51 comments

24 in this archive, depth 4

best — the order this archive was captured in

u/kian_solberg230 points·6 months ago

Questions about oral contraceptive absorption and gastric emptying are legitimate pharmacology questions with product-specific answers. A pharmacist can answer them properly; a board cannot.

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u/signe_villalobosOP165 points·6 months ago

PCOS and insulin resistance are the thread that runs through this board

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u/aleksi_eriksen153 points·6 months ago

Started logging the cycle in the same sheet as the dose. Three months later the pattern was obvious and it had been invisible before.

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u/joaquin_wojcik121 points·6 months ago

Not convinced by the attribution. That pattern tracks the cycle in your own log more closely than it tracks the dose.

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[deleted]79 points·6 months ago

[deleted]

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u/wholesome_lurkerMOD68 points·6 months ago·edited

Retitled to distinguish a cycle-linked pattern from a dose-linked one.

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u/nora_oyelaran34 points·6 months ago·edited

Perimenopausal, or is that a separate question?

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u/viktor_laurent11 points·6 months ago

Agreed that the vocabulary here is imprecise and it causes people to answer different questions to the ones asked.

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u/idris_kimani20 points·6 months ago

perimenopause and this overlap in ways nobody has good data on

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u/blunt_coldbox_202421 points·6 months ago

Brought the cycle-annotated log to an appointment and it changed the conversation completely.

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u/sterile_field_steph95 points·6 months ago

Is this a PCOS diagnosis or an insulin resistance finding?

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u/ferran_mensah33 points·6 months ago

Push back: PCOS as a diagnosis and insulin resistance as a finding are not interchangeable, and the thread is using them as one.

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u/enzo_fonseca8 points·6 months ago·edited

Push back: PCOS as a diagnosis and insulin resistance as a finding are not interchangeable, and the thread is using them as one.

Adding the one thing nobody warns about — fertility can change, and quickly.

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u/zeynep_weiss5 points·6 months ago

Disagree — that is a general claim about absorption and the specific question needs a pharmacist rather than a board.

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u/honest_syringe58 points·6 months ago

I would not read one person’s cycle-linked experience as a general pattern. The variation here is enormous.

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u/emeka_chowdhury43 points·6 months ago

Asked a pharmacist about the absorption question rather than the internet. Ten minutes, clear answer, done.

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u/honest_syringe_202534 points·6 months ago

symptom patterns can track the cycle rather than the dose

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u/step_therapy_s18 points·6 months ago·edited

Careful — anything touching pregnancy is not a board question in any form.

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u/elodie_kuipers13 points·6 months ago

the same dose can feel different at different points in the month

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u/neha_rahimi63 points·6 months ago·edited

The hair shedding was the thing that frightened me most and the thing that mattered least. It stopped.

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u/samir_falk25 points·6 months ago

Trial populations for the major programmes were not designed around the questions this board asks most often, which is why the evidence base here is genuinely thinner rather than merely harder to find.

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u/dilara_szabo12 points·6 months ago

Yes. The research gap is genuine; most of the trials were not designed to answer these questions.

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u/ewan_zielinski10 points·6 months ago

Have you asked a pharmacist about the absorption question specifically?

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u/ferran_laurent19 points·6 months ago

Cosigning on fertility changing with weight loss. It catches people who were not expecting it at all.

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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