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c/bloodwork·submitted 6 months ago by u/edit_for_clarity

why does nobody talk about baseline labs

Questionbranch of 7 comments

Trying to get a straight answer on this: why does nobody talk about baseline labs. Why so many single values look alarming and turn out to be nothing. A reference interval is built to contain about 95% of a healthy reference population, so one test in twenty falls outside one by construction. Add biological…

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7 comments, started 5 months ago
u/chidi_abubakar21 points·5 months ago

Agreed. The trend is the signal. A single value is a snapshot of one morning.

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u/janek_ferrari6 points·5 months ago

Time of day, fasting state, hydration and recent exercise all move common markers. Standardising the draw conditions is free and it removes most of the apparent variability.

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u/osman_eriksen5 points·5 months ago

Substantial weight loss independently moves lipids, liver enzymes and several other markers. Attributing a change to a compound while losing weight is confounded by design.

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u/edit_for_clarityOP4 points·5 months ago

draw at the same point in the week if you want comparability

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u/emeka_chowdhury0 points·5 months ago

draw at the same point in the week if you want comparability

Agreed — and standardising the draw conditions is the cheapest improvement available.

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u/yara_mensah3 points·5 months ago·edited

Small fix — a reference interval is not a treatment target, and the post above uses them interchangeably.

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u/tomas_kimani2 points·5 months ago

What did the repeat show?

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