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c/bloodwork·posted 1 year ago by u/ismael_eriksen

stalled for 15 weeks at 1.7mg and I refuse to panic this time

Baseline Clean Column ×7 Sourced ×3 Slow Clap ×3

stalled for 15 weeks at 1.7mg and I refuse to panic this time. It is the sort of thing everyone half-believes and nobody writes down.

The numbers the title promised, since a headline without them is worthless: 15 weeks and 1.7mg. Everything below is context for those.

Added ApoB to the panel after a thread here. It told me something the standard lipid panel had been hiding.

Compared two draws across two labs and spent a week worrying before finding out the assays were different.

Tell me where this is wrong. That is the useful part of posting it.

5,103 up / 294 down95% upvoted43 commentsid 15gg5e18 Sep 2024

43 comments

8 in this archive, depth 4

best — the order this archive was captured in

u/constipation_clubside effects-8 points·1 year ago

The confounding problem, stated plainly, because this board keeps stepping on it.

Substantial weight loss moves lipids, liver enzymes, insulin sensitivity markers and several others in its own right. If you are losing weight while taking something, any change in those markers has at least two candidate explanations and you cannot separate them from your own panel.

What you can do is standardise, take a baseline, keep the series long, and be honest in your posts about what is and is not attributable. The threads that say "this compound did X to my triglycerides" almost never have the design to support the claim, mine included.

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u/nabila_bakken1 point·1 year ago

hydration status moves a surprising number of markers

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u/liver_enzyme_liz1 point·1 year ago

Different laboratories use different assay platforms with different calibration. Comparing across labs adds a systematic offset that is invisible on the report.

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u/bac_water_banditreconstitution1 point·1 year ago

the trend line matters more than any single value

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u/nikhil_asante1 point·1 year ago

same lab, same conditions, or you are comparing noise

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u/burned_once_twice800 points·1 year ago

How many weeks between the two measurements?

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u/ismael_eriksenOP567 points·1 year ago·edited

That is a non-fasting value and the interval you are comparing it against is a fasting one.

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u/cold_chromatogram31426 points·1 year ago·edited

Not convinced by the attribution. Weight loss alone moves that marker and you have no way to separate the two.

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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