u/iman_falk

Did the maths give you a whole number of units, or a fraction?

Research-use-only material is not approved for human use, so treat everything in this thread as arithmetic about solutions rather than instructions for a person.

Right — the volume you add is the only variable you control here, and the cake does not change it meaningfully.

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss.

This is the shape almost everybody here describes, and it is the single most reassuring thing in the thread.

Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.

Took a baseline the week before starting purely because this board told me to. Best five minutes I have spent on this.

holding a dose an extra month is a legitimate answer to bad tolerance

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

the appetite signal and the scale move on different clocks

Week 73: 19kg down, constipation basically gone since about week 2, and the honest headline is that nothing dramatic happened. It was boring and it worked.

Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.

Genuine question — is the appetite effect still there, or is it just the scale that has paused?

Shook the first vial because nobody told me not to. It was fine, but I have swirled every one since.

The arithmetic in full: concentration is mass over volume, so 15mg into 3mL gives 5mg/mL. A U-100 syringe is graduated at 100 units per millilitre, so 1.5mg is 1.5 divided by 5 millilitres, which is 30 units.

Which day of the week relative to the shot does it hit?

one measurement is a point, two is a line, three is a trend

Disagreeing with this bit: that change is confounded by the weight loss itself and cannot be attributed.

Added ApoB to the panel after a thread here. It told me something the standard lipid panel had been hiding.

Same view — ApoB if you add one thing. It answers a question the standard panel only gestures at.

That is a non-fasting value and the interval you are comparing it against is a fasting one.

Compared two draws across two labs and spent a week worrying before finding out the assays were different.

That comparison crosses two labs with different assays. The difference you are describing may be the method.

I would push back gently. Going up because the scale paused is the single most common mistake described on this board.

fibre and water before you buy anything to fix it

Is that the same assay, or did the lab change platforms?

The appetite thing was the surprise. I expected to feel full. What I got was simply not thinking about food between meals.

Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the nausea usually fades at a stable dose.

swirl, never shake

How long was the stall before you decided it was a stall?

Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.

staying at 1.7mg for an extra month is a legitimate plan

endpoint_creep is describing the standard shape here and it matches the trial data better than most anecdotes do.

fatigue plus low intake is usually just low intake

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

That is sterile water, not bacteriostatic. Same appearance, different product, and it matters for a multi-draw vial.

a rough fortnight at each step is normal, a rough three months is not

write the concentration on the vial in marker, that is the whole post

Minor fix — the half-life is about a week, not about a day. The rest of your point stands.

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

same lab, same conditions, or you are comparing noise

Same. I sat at 0.25mg for three months because it was working and there was nothing to fix.

Yes. Week 60 is when almost everybody writes the "is it still working" post, and almost everybody is fine.

Small fix — a reference interval is not a treatment target, and the post above uses them interchangeably.