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c/sideeffects·posted 1 year ago by u/ipamorelin_i

gallbladder — 15 things I got wrong before I got it right

Question Receipts ×1 Sourced ×2 Cold Box ×2

gallbladder — 15 things I got wrong before I got it right. It is the sort of thing everyone half-believes and nobody writes down.

Held the dose for an extra six weeks instead of stepping. The muscle cramps settled and I lost the same amount anyway.

The pattern almost everyone here describes, written out once so it can be linked.

A step up is followed by a rough window — commonly constipation arriving the day after the shot and easing by day four, worst in the first fortnight, then flattening out. At a stable dose it usually settles further. Constipation and fatigue tend to track intake and fluid rather than the compound directly, which is why the unglamorous answers work.

What sits outside that pattern: severe pain, symptoms that appear from nowhere weeks into a stable dose, or anything getting worse rather than better over a month. None of that is a board question and none of us can answer it for you.

Keeping a log, and what to put in it.

One line a day: dose, day since injection, what the symptom was and how bad out of five, and roughly what you ate. Two months of that fits on one page and the pattern is obvious on paper in a way it never is in your head.

Mine showed a clean day-two-to-day-four window I had been describing as "random". Once you can see the pattern you can plan around it, and planning around it is most of the relief.

Tell me where this is wrong. That is the useful part of posting it.

7,390 up / 603 down92% upvoted67 commentsid azondu11 Nov 2024

67 comments

30 in this archive, depth 4

best — the order this archive was captured in

u/piotr_bruun1.4k points·1 year ago

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

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u/nabila_ogunleye1k points·1 year ago

That reads like advice, and none of us can give it. Describe what you did, not what somebody else should do.

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u/ipamorelin_i239 points·1 year ago

That reads like advice, and none of us can give it.

Disagreeing with this one line: that symptom is not on the wait-and-see list and should not be posted as though it is.

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u/adaeze_batista182 points·1 year ago

Disagreeing with this one line: that symptom is not on the wait-and-see list and should not be posted as though it is.

ipamorelin_i is right about the timing. The day-of-week pattern is the diagnostic bit, not the severity.

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u/ipamorelin_iOP125 points·1 year ago

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/baseline_drifteranalytical579 points·1 year ago·edited

Disagree. Severe abdominal pain is not on the list of things to wait out, and this board should not be treating it as one.

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u/leila_silva198 points·1 year ago

Pushback: you changed the dose, the meal timing and the training in the same fortnight, so the attribution is guesswork.

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[removed]84 points·1 year ago

[removed by moderator]

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u/isabela_nilsen112 points·1 year ago

Right, and the hair thing is worth repeating: it tracks the rate of loss rather than the compound, and it stops.

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u/insulin_syringe_ian163 points·1 year ago

constipation for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

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u/sequence_checkerresearch peptides463 points·1 year ago

On buying things to fix side effects, which I did extensively and would not do again.

The interventions that changed anything for me were all behavioural and free: smaller meals, eating slower, stopping food a few hours before sleep, more fibre and considerably more water. The things I bought did nothing I could detect, and I was motivated to detect something.

The other lever, which people forget, is time at dose. Holding rather than stepping is a legitimate plan and it fixed my tolerance where nothing else did.

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u/nausea_notesside effects281 points·1 year ago

On buying things to fix side effects, which I did extensively and would not do again.

Adding to this — holding the dose rather than stepping is the option people forget they have.

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u/reta_and_regret329 points·1 year ago

smaller meals, earlier, is the boring advice that works

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u/iman_falk224 points·1 year ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/elin_lundgren206 points·1 year ago

Mine settled at week 56 and has not come back since, across two more steps.

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u/zaid_balogun99 points·1 year ago

Cosigning the fibre and water answer. Unglamorous, free, and it fixed it for me inside a week.

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u/aa_analysis_andy61 points·1 year ago

Same pattern here. It settled at a stable dose without me doing anything clever.

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u/naomi_erdogan73 points·1 year ago

Mine settled at week 56 and has not come back since, across two more steps.

Agreed, with the caveat that "usually settles" is not "always settles" and the exceptions should still get asked about properly.

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u/leila_silva-14 points·1 year ago

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

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u/ipamorelin_iOP114 points·1 year ago

What is intake actually looking like — fibre and water especially?

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u/janoshik_junkieindependent tester71 points·1 year ago

What is intake actually looking like — fibre and water especially?

This is the shape almost everybody here describes, and it is the single most reassuring thing in the thread.

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u/placebo_arm_pam41 points·1 year ago

reflux at night, try not eating in the three hours before bed

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u/chidi_abubakar0 points·1 year ago

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

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u/constipation_clubside effects1 point·1 year ago

holding a dose an extra month is a legitimate answer to bad tolerance

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u/marta_marchand1 point·1 year ago

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

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u/fibre_forward1 point·1 year ago·edited

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 20 probably does not, and that is worth saying to a clinician rather than to us.

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u/tomas_lehtinen0 points·1 year ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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u/rina_bergstrom1 point·1 year ago

hair shedding follows the weight loss, not the drug, and it stops

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u/ipamorelin_i1 point·1 year ago

fibre and water before you buy anything to fix it

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u/rina_bergstrom1 point·1 year ago·edited

nausea on day two and gone by day four is the standard shape

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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