[Lab] 8th independent test on MKM — 97.9% on a claimed 97.5%, and the trend is the interesting part
Filing this under things worth writing down: 8th independent test on MKM — 97.9% on a claimed 97.5%, and the trend is the interesting part.
Numbers, in the order they matter: 97.9% and 97.5%.
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
Screenshot none of this. Read the whole thread, including the parts where I am told I am wrong.
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nofollow and sponsored; nobody here is paid for it.best — the order this archive was captured in
Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.
Removed the dose recommendation. You can describe what you did; you cannot tell somebody else what to take.
Same injection day each week, or has it drifted?
Does nausea track the day after the shot, or is it there all week?
Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.
iman_falk is describing the standard shape here and it matches the trial data better than most anecdotes do.
Not convinced. You changed the dose and the week at the same time, so you cannot attribute the change to either.
staying at 2.4mg for an extra month is a legitimate plan
nausea that arrives on day two and fades by day four is the standard shape
2.4 is a ceiling, not a target
That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.
protein first, then everything else gets easier
Sat at 0.5mg for four months because it was doing the job. Everyone told me to go up. The one time I did, the only thing that changed was the fatigue.
Not convinced.
Disagree with this specific line. A pause at 1.0mg is not evidence that 1.0mg has stopped working.
the ladder exists because the gut needs the time, not because the pharmacy likes paperwork
the food noise going quiet is the effect people actually describe
Same. I sat at 0.25mg for three months because it was working and there was nothing to fix.
Same.
Adding one thing to this: the appetite effect and the scale run on separate clocks, so both halves can be true at once.
What did week 13 look like compared with this one? The month either side is the useful comparison.
Careful. A four-week stall is inside normal variation and treating it as failure is how people escalate for no reason.
sema is weekly for a reason, the half-life does the smoothing
Minor fix — the half-life is about a week, not about a day. The rest of your point stands.
Minor fix — the half-life is about a week, not about a day.
Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.
fatigue made the first fortnight rough at each step up, then flattened out. Predictable enough that I started planning around it.
Yes — and the honest version is that most of the "it stopped working" posts turn out to be a normal fortnight of water weight.
Kept a log from week one and the single most useful column turned out to be waist, not weight.
the scale is the least sensitive instrument you own
The mental model that finally made this click for me: there are two curves, and people watch the wrong one.
The first is exposure, which is set by the dose and smoothed by a week-long half-life. It changes when you change the dose and then settles over about a month. The second is body weight, which is exposure filtered through appetite, food, water, sleep, training and the scale itself, and which moves in steps rather than a line.
Almost every "it stopped working" post is somebody watching curve two over a fortnight and drawing conclusions about curve one. If the appetite effect is still there, exposure is fine. Wait the month.
The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.
Did protein intake change in the same window?
- 1Not convinced. You changed the dose and the week at the same time, so you…11 comments in this branch · started by u/source_or_silence