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[CGM] what the postprandial curve actually looks like before and after
what the postprandial curve actually looks like before and after. Searched first, found three threads that contradict each other, hence the post. Continuous monitoring…
u/hugo_norgaard
Contributes reviews on supplier material. Based in Ibadan.
member · joined 14 May 2025
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comment on [Caution] stacking with a sulfonylurea is a real hypo risk, not a theoretical one in c/t2dglp1 · 12 points · 2 days ago
dose for glycaemic control is not the same conversation as dose for weight
comment on what is bac water and why does everyone keep saying it in c/newbiequestions · 28 points · 6 days ago
Yes — nobody here is your clinician, and the good answers on this board all end with that.
comment on [Long Term] found my lowest effective dose by going down, not up in c/maintenancephase · 9 points · 9 days ago
I would not treat a two-kilo range as drift requiring action. That is ordinary weight variation.
comment on [Results] two years, weight stable within 3kg, dose at a quarter of peak in c/maintenancephase · 20 points · 20 days ago
I would not treat a two-kilo range as drift requiring action.
Disagreeing with this bit: a two-kilo range is not drift and treating it as a problem creates one.
comment on [Results] 37 weeks on 15mg, full numbers, ask me anything boring in c/t2dglp1 · 5 points · 1 months ago
Have you taken this to whoever manages your diabetes?
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[Results] 37 weeks on 15mg, full numbers, ask me anything boring
37 weeks on 15mg, full numbers, ask me anything boring. This is a description of what happened to me and not a plan for anybody else. To save the first four comments:…
comment on clothes fit the same for 14 months and it is genuinely strange in c/maintenancephase · 16 points · 1 months ago
Small fix — you have described interval stretching and called it a dose reduction. The exposure profiles differ.
comment on 23 months in and week one is still the thing I get wrong in c/newbiequestions · 5 points · 1 months ago
Appetite change and weight change are different measurements on different timescales. The first is usually noticed first and the second lags it.
comment on 24 months in and metformin is still the thing I get wrong in c/t2dglp1 · 0 points · 1 months ago
Postprandial excursions typically respond earlier than fasting glucose, so the sequence people observe is not a sign that something is not working.
comment on regain: what the trials say vs what this community says in c/maintenancephase · 1 points · 1 months ago
Chased the last three kilos with a dose increase and got a fortnight of injection-site soreness and no change in the number.
comment on [Discussion] can we stop arguing about TRIUMPH until somebody posts a number in c/trialwatch · 5 points · 1 months ago
A confidence interval is the range of effects compatible with the data. Two trials with overlapping intervals have not disagreed, whatever their point estimates look like next to each other.
comment on stalled for 14 weeks at 7.5mg and I refuse to panic this time in c/newbiequestions · -34 points · 2 months ago
a COA is a certificate of analysis, the lab document for a batch
comment on tried glycaemic control for 4 weeks. here is what happened. in c/t2dglp1 · 138 points · 2 months ago
the diabetes trials report different endpoints from the obesity ones
comment on my triglycerides moved and I cannot work out whether what is is why in c/newbiequestions · 10 points · 3 months ago
Yes — nobody here is your clinician, and the good answers on this board all end with that.
comment on [Discussion] the endpoint advice in here is 3 years out of date in c/trialwatch · 10 points · 3 months ago
discontinuation rate is a result, not a footnote
comment on [Discussion] the endpoint advice in here is 3 years out of date in c/trialwatch · 18 points · 3 months ago
SURPASS is the diabetes programme and reports glycaemic endpoints
comment on the STEP question that gets asked weekly, answered properly in c/trialwatch · 5 points · 3 months ago
check who the comparator was before you compare anything
comment on how much of what we believe about endpoint actually comes from SURMOUNT threads in c/trialwatch · 6 points · 5 months ago
That is a relative risk reduction. Quoting it without the absolute numbers overstates the case considerably.
comment on how much of what we believe about endpoint actually comes from SURMOUNT threads in c/trialwatch · 74 points · 5 months ago
Same. A press release is a claim about a result; the publication is the result.
comment on [Discussion] lowest effective dose is doing more work than we give it credit for in c/maintenancephase · 20 points · 6 months ago
I would not treat a two-kilo range as drift requiring action. That is ordinary weight variation.
comment on someone explain FLOW to me like I have not read a paper in years in c/trialwatch · 86 points · 6 months ago
What was the discontinuation rate?
comment on lowest effective dose — my 7-week log, condensed into one table in c/maintenancephase · 13 points · 6 months ago
Not convinced. Interval stretching changes your exposure profile, not just the total, and the two are not equivalent.
comment on small win: goal weight stopped being a problem at week 19 in c/maintenancephase · 31 points · 7 months ago
the habits are the part that has to outlive the dose
comment on [Discussion] can we stop arguing about T2D until somebody posts a number in c/t2dglp1 · 14 points · 8 months ago
a single high reading is not a trend
comment on does regain actually matter or is it forum lore at this point in c/maintenancephase · 15 points · 9 months ago
regain after stopping is the expected outcome, not a personal failure
comment on [Meta] the FLOW rule is doing its job and people should stop complaining in c/trialwatch · 1 points · 9 months ago
trial populations get support that nobody on this board gets
comment on [Meta] proposal — a flair for dose stretching posts in c/maintenancephase · 1 points · 10 months ago
stretching the interval is not the same as reducing the dose
comment on is it normal to get early fullness at week 90 in c/maintenancephase · 1 points · 11 months ago
a few kilos of drift is not a relapse
comment on [Discussion] the endpoint advice in here is 3 years out of date in c/trialwatch · 67 points · 12 months ago
Same. A press release is a claim about a result; the publication is the result.
comment on what would you tell week-1 you about CGM in c/t2dglp1 · 33 points · 1 year ago
variability matters as much as the mean
comment on [Discussion] can we stop arguing about TRIUMPH until somebody posts a number in c/trialwatch · -35 points · 1 year ago
read the endpoint before you read the headline
comment on [Question] normal — what am I missing here in c/newbiequestions · 5 points · 1 year ago
Week 4 for me was completely flat and I was convinced something was wrong. It was not. Month two was where everything happened.
comment on 13 months in and basics are still the thing I get wrong in c/newbiequestions · 82 points · 1 year ago
Took three weeks to understand titration and about ten seconds once somebody explained it as a tolerance ladder.
comment on switched from 1.7mg to 2.4mg and nausea got better, not worse in c/maintenancephase · 1 points · 1 year ago
Correction: that trial measured regain after withdrawal, not failure of the drug during treatment. Very different claim.
comment on switched from 0.5mg to 2.4mg and early fullness got better, not worse in c/newbiequestions · -34 points · 1 year ago
no question is too basic here, that is the entire point of the board
comment on hazard ratio is the most under-discussed thing on this board in c/trialwatch · 712 points · 1 year ago
The registered protocol is public. Comparing the registered primary endpoint with the reported one is a two-minute check and it is how outcome switching gets caught.
comment on three years of beginner threads, summarised so you do not have to read them in c/newbiequestions · -10 points · 1 year ago
Research-use-only material is not approved for human use. That is a plain statement of regulatory fact and it belongs in every beginner thread.
comment on anyone else notice hypoglycaemia kicking in around week 8 in c/t2dglp1 · 6 points · 1 year ago
a single high reading is not a trend
comment on three years of week one threads, summarised so you do not have to read them in c/newbiequestions · 0 points · 1 year ago
Left up.
Slight disagreement with this bit only, because a beginner reading it might take it as a plan rather than a description.