dual agonist

Check-in as promised in the title: small win: hepatic fat stopped being a problem at week 91. Nothing containing this compound is approved anywhere. Research-use-only…

someone explain survodutide to me like I have not read a paper in years. I am not trying to be the "source?" guy. I would just like a source. Assumed the weight numbers…

Six-word version is the title — anyone else notice survodutide kicking in around week 93 — and the rest is context. Read the phase 2 hepatic paper properly and the…

Check-in as promised in the title: 65 weeks on 15mg, full numbers, ask me anything boring. The relevant figures are 65 weeks and 15mg, and they come from the same log I…

4 months in and MASH is still the thing I get wrong. Numbers below. Ask me the boring questions, they are the useful ones. Numbers, in the order they matter: 4 months.…

WWB survo — Medutest came back 99.2% against a claimed 98.5%. One vial, one service, one member paying, which is the only kind of result this board should treat as…

tirzepatide — 9 things I got wrong before I got it right. Change my mind, genuinely — I have no stake in being right about this. Switching from semaglutide, since three…

Check-in as promised in the title: is it normal to get muscle cramps at week 54. Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped…

why does nobody talk about dual agonist, and I want the answer with the reasoning attached rather than just the conclusion. Assumed the weight numbers were the point…

hepatic fat: the version I wish someone had shown me in week 1. Full detail below, and I have tried to keep the editorialising out of it. Bought small because the…

VendorInvestigate results are area% by default and people keep forgetting. That is the post. The justification is underneath. Week 85 was the first time the scale moved…

The phase 2 MASH results ( NEJM , 2024) are, to me, the most underdiscussed thing in this whole space. Biopsy-confirmed endpoints. Not an ALT screenshot, not imaging,…

am I the only one who found Zepbound harder than the injections, and I want the answer with the reasoning attached rather than just the conclusion. The four-week…

Thinking out loud about this: three years of MASH threads, summarised so you do not have to read them. Spent an evening on the histology scoring system and understood…

Trying to get a straight answer on this: what would you tell week-1 you about GIP. Vials and pens carry the same molecule; what differs is fill volume, device tolerance…

MASH — my 24-week log, condensed into one table, which sounds obvious until you try to state the evidence for it. It is a dual agonist at the GLP-1 and glucagon…

we are measuring tirzepatide at the wrong time and calling it noise. Change my mind, genuinely — I have no stake in being right about this. Went 10 to 12.5 on the…

Trying to get a straight answer on this: why does nobody talk about survodutide. Went slowly because everything published describes a deliberate escalation. That is the…

dual agonist is the most under-discussed thing on this board. I have gone back and forth on this for months. Phase 2 in a biopsy-confirmed population is a demanding…

Short public-service post: dual agonist is not what most of this community thinks it is. Asked here what the difference was between the imaging and biopsy endpoints and…

GGPeps survo — VendorInvestigate came back 97.9% against a claimed 97.0%, and before anyone asks: same batch throughout, single submission, no cherry-picking between…

my resting HR went from 58 to 66 on titration and settled back. Not a hot take, just something I have not seen said plainly here. Held 7.5 for five months. Everyone…

Result first, context after: 8th independent test on JEEP — 97.2% on a claimed 97.0%, and the trend is the interesting part . Everything below is how it was ordered,…

three years of glucagon threads, summarised so you do not have to read them, which sounds obvious until you try to state the evidence for it. It is a dual agonist at…

Posting the boring version of a titration log because I wish I'd had one with this much unremarkable detail before I started. Weeks 1–4: starter dose, mild fatigue day…