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c/tirzepatide·submitted 2 months ago by u/sten_palacios

[Lab] split one vial across Medutest and Janoshik — 99.3% and 98.7%

Labbranch of 9 comments

Filing this under things worth writing down: split one vial across Medutest and Janoshik — 99.3% and 98.7%. To save the first four comments: 99.3% and 98.7%. Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry,…

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9 comments, started 2 months ago
u/ghrp_history77 points·2 months ago·edited

The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.

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u/endpoint_creep37 points·2 months ago

Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.

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u/laila_wikstrom11 points·2 months ago

the reflux profile is genuinely gentler than people expect coming from sema

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u/tarek_kirchner-23 points·2 months ago·edited

sulphur burps are the signature complaint and they are not dangerous

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u/georgi_chowdhury0 points·2 months ago

the reflux profile is genuinely gentler than people expect coming from sema

Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.

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u/samir_falk30 points·2 months ago

28kg over 88 weeks, never went past 10mg, and food noise stayed mild the whole way. Posting because the loud threads are all 15mg.

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u/hair_shed_hannah13 points·2 months ago

the four-week step schedule is the label, not folklore

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u/hana_pereira21 points·2 months ago

Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.

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u/fatima_wojcik15 points·2 months ago

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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