reading 15mg threads from 2024 and half of it aged badly
reading 15mg threads from 2024 and half of it aged badly. It is the sort of thing everyone half-believes and nobody writes down.
Hard numbers: 15mg. Anything softer than that is flagged as an impression.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
That is everything I have. The rest is opinion and I have tried to keep it out.
best — the order this archive was captured in
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads.
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
SURMOUNT-1 landed around 21% at 72 weeks on the top arm
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
Trial identifiers corrected in the title. SURMOUNT and SURPASS are different programmes.
What is the waist doing? That is usually the number still moving during a scale stall.
Switching from semaglutide, since three people asked in this thread alone.
There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that the first month after a switch is often flat, that the appetite effect feels differently shaped rather than simply stronger, and that starting at the bottom of the ladder again is the common approach.
None of that is a recommendation. It is what the threads say, and the threads are not a clinic.
Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.
Yes.
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.
Are you comparing yourself with the trial mean or with the people who post the most?
Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
Yes — 10mg being a genuine landing place for a lot of people is underrated. There is no medal for 15.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
stepping every four weeks is a ceiling on speed, not a schedule you must hit
Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.
This matches mine. Milder muscle cramps than I expected, and what there was settled inside a fortnight of each step.
Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.
Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.
the fatigue profile is genuinely gentler than people expect coming from sema
13kg over 28 weeks, never went past 10mg, and early fullness stayed mild the whole way. Posting because the loud threads are all 15mg.
Have you held a step for longer than the four-week minimum at any point?
switching from sema is not a dose conversion, there is no clean equivalence
the appetite effect is blunter than sema, in a good way, most weeks
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
What step are you on and how long have you been there?
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
Week 75 was the first time the scale moved after a five-week stall. I changed nothing in that window.
Same experience with the appetite effect being flatter across the week rather than front-loaded.
- 113kg over 28 weeks, never went past 10mg, and early fullness stayed mild the…9 comments in this branch · started by u/neha_falk
- 2Switching from semaglutide, since three people asked in this thread alone.…7 comments in this branch · started by u/swirl_dont_shake