three years of 15mg threads, summarised so you do not have to read them
three years of 15mg threads, summarised so you do not have to read them. It is the sort of thing everyone half-believes and nobody writes down.
The numbers the title promised, since a headline without them is worthless: 15mg. Everything below is context for those.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
Sceptical readings welcome. The confident ones are the ones I distrust.
best — the order this archive was captured in
Trial identifiers corrected in the title. SURMOUNT and SURPASS are different programmes.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
dual agonist, so the GIP arm is doing something the sema threads will not tell you about
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads.
samir_falk is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.
sulphur burps are the signature complaint and they are not dangerous
Switching from semaglutide, since three people asked in this thread alone.
There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that the first month after a switch is often flat, that the appetite effect feels differently shaped rather than simply stronger, and that starting at the bottom of the ladder again is the common approach.
None of that is a recommendation. It is what the threads say, and the threads are not a clinic.
Pen or vial? The step sizes available differ and it changes this answer.
What is the waist doing? That is usually the number still moving during a scale stall.
Did you come to this from sema, and if so how long was the gap?
Which week did the appetite change actually land for you?
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That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
hold the dose that works, the ladder is not a leaderboard
2.5 is the starter dose and it is not meant to be the dose that works
SURMOUNT-1 landed around 21% at 72 weeks on the top arm
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
Week 67 was the first time the scale moved after a five-week stall. I changed nothing in that window.
the four-week step schedule is the label, not folklore
Does nausea follow the day after the shot, or is it spread across the week?
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
zepbound and mounjaro are the same compound with different labels
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
20kg over 66 weeks, never went past 10mg, and injection-site soreness stayed mild the whole way. Posting because the loud threads are all 15mg.
week 6 is early to draw any conclusion at all
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
Are you comparing yourself with the trial mean or with the people who post the most?
Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.
Have you held a step for longer than the four-week minimum at any point?
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
- 1Did you come to this from sema, and if so how long was the gap?14 comments in this branch · started by u/ferritin_low