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c/tirzepatide·submitted 2 years ago by u/rania_diallo

unpopular opinion: most of what gets said here about GIP is guesswork

Trial Databranch of 7 comments

unpopular opinion: most of what gets said here about GIP is guesswork. Making the case below, and I expect to lose some of it in the comments. SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two…

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7 comments, started 2 years ago
u/vito_chowdhury46 points·2 years ago

Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.

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u/emil_barros17 points·2 years ago

That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.

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u/sten_bhattacharya12 points·2 years ago·edited

Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.

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u/search_before_post14 points·2 years ago

Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.

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u/line_petrov3 points·2 years ago

Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.

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u/blunt_coldbox291 point·2 years ago

Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.

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u/santiago_villalobos1 point·2 years ago

Did you come to this from sema, and if so how long was the gap?

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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