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Single comment threadYou are looking at one branch of [Lab] Homopeptide survo — Medutest came back 98.4% against a claimed 98.0% — 61 comments in the full submission. View in context.
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c/survodutide·submitted 1 year ago by u/britt_abubakar

[Lab] Homopeptide survo — Medutest came back 98.4% against a claimed 98.0%

Questionbranch of 10 comments

Homopeptide survo — Medutest came back 98.4% against a claimed 98.0%. One vial, one service, one member paying, which is the only kind of result this board should treat as evidence. The relevant figures are 98.4% and 98.0%, and they come from the same log I have kept the whole time. Sent a vial to PeptideMeter…

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10 comments, started 1 year ago
u/camila_marchand173 points·1 year ago

It is a dual agonist at the GLP-1 and glucagon receptors. The glucagon arm is associated with increased energy expenditure and with effects on hepatic fat, which is why the development programme is oriented towards liver disease.

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u/protein_first_pnutrition40 points·1 year ago

Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use.

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u/titration_marshalmod · c/semaglutide31 points·1 year ago

That is an escalation schedule for an unapproved compound and this board does not host those.

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u/renzo_yildiz130 points·1 year ago

Yes — histological endpoints are a far harder bar than the surrogate measures people are used to quoting.

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u/slow_logbook_notes3047 points·1 year ago

Same. Very thin independent data on this one, which should make everybody here more tentative than they are.

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u/cesar_ivaturi31 points·1 year ago

read the histology endpoint definitions before quoting a response rate

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u/milan_mensah16 points·1 year ago

That figure is from the obesity programme, and this thread is about the hepatic one.

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u/joaquin_ivaturi39 points·1 year ago

Push back: the evidence here is phase 2, in a specific population, and it does not support a general ranking.

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u/valeria_karlsen12 points·1 year ago

not approved anywhere, and the boards forget that constantly

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u/lina_ndiaye38 points·1 year ago

Disagree — that is a weight endpoint from a different programme and you are quoting it in a hepatic context.

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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