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c/survodutide·posted 1 year ago by u/kaia_wojcik

is it normal to get muscle cramps at week 88

Trial Data Cold Box ×5 Long Haul ×3 Receipts ×1

Check-in as promised in the title: is it normal to get muscle cramps at week 88.

Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use.

Independent purity results for this compound are very sparse across the whole site, which means any impression about consistency is built on almost nothing.

Screenshot none of this. Read the whole thread, including the parts where I am told I am wrong.

3,149 up / 489 down87% upvoted32 commentsid 1wnabx12 Mar 2025

32 comments

9 in this archive, depth 4

best — the order this archive was captured in

u/patient_labslip_log261 points·1 year ago

the titration in the trials was slow and deliberate

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u/sofia_ferreira-38 points·1 year ago

Disagree — that is a weight endpoint from a different programme and you are quoting it in a hepatic context.

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u/milan_mensah1 point·1 year ago

This. Biopsy-confirmed and imaging-suggested are different evidentiary categories and get run together constantly.

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u/kaia_wojcikOP1 point·1 year ago

Small fix — dual agonist, GLP-1 and glucagon. No GIP arm in this molecule.

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u/kaia_wojcikOP0 points·1 year ago

Which endpoint — histological response, fibrosis improvement, or fat fraction?

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u/honest_syringe_pls1 point·1 year ago

Correction: that is the imaging endpoint, not the histological one. The paper reports both and they differ substantially.

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u/paper_trail_paulavetting1 point·1 year ago

That figure is from the obesity programme, and this thread is about the hepatic one.

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u/incretin_ivyMOD258 points·1 year ago

Retitled to name the endpoint. Histological and imaging results are not interchangeable and the original title implied they were.

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u/kaia_wojcikOP129 points·1 year ago

Correcting myself: the readout I quoted was the 4-week interim rather than the endpoint.

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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