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c/survodutide·submitted 1 year ago by u/trialwatch_theo

glucagon is the most under-discussed thing on this board

Cautionbranch of 9 comments

Something I keep coming back to: glucagon is the most under-discussed thing on this board. Imaging-derived liver fat fraction is a surrogate. It correlates with histology imperfectly, and a trial reporting one is not reporting the other. Nothing containing this compound is approved anywhere. Research-use-only…

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9 comments, started 1 year ago
u/rania_marchand25 points·1 year ago

How fast was the escalation in that protocol?

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u/tired_ledger_ftw35 points·1 year ago

glucagon agonism and energy expenditure is the mechanistic thread

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u/customs_seizure_sid21 points·1 year ago

Has anyone posted an independent purity result for this compound?

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u/joaquin_ivaturi11 points·1 year ago·edited

Asked here what the difference was between the imaging and biopsy endpoints and got a genuinely excellent answer.

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u/elin_ferrari20 points·1 year ago

the titration in the trials was slow and deliberate

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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