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c/sideeffects·posted 5 months ago by u/janoshik_junkie

is it normal to get reflux at week 5

Question Receipts ×7 Slow Clap ×2

Six-word version is the title — is it normal to get reflux at week 5 — and the rest is context.

reflux for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

Bought four different things to fix my sulphur burps. What actually worked was eating half as fast.

Not medical advice, obviously, and nothing here is approved for human use. One person with a spreadsheet.

2,518 up / 259 down91% upvoted62 commentsid 1bvptj13 Feb 2026

62 comments

29 in this archive, depth 6

best — the order this archive was captured in

u/usp_appendixcompendial428 points·5 months ago

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

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u/constipation_clubMOD236 points·5 months ago

Left up. It is a description of one person’s week and it is flagged as such.

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u/aleksi_lehtinen185 points·5 months ago

fatigue plus low intake is usually just low intake

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u/yannick_barros0 points·5 months ago

fatigue plus low intake is usually just low intake

aleksi_lehtinen is right about the timing. The day-of-week pattern is the diagnostic bit, not the severity.

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u/ferran_dahlberg1 point·5 months ago

Same pattern here. It settled at a stable dose without me doing anything clever.

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[deleted]1 point·5 months ago

[deleted]

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u/nausea_notesside effects149 points·5 months ago

fatigue plus low intake is usually just low intake

Adding to this — holding the dose rather than stepping is the option people forget they have.

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u/milan_villalobos72 points·5 months ago

the fatigue that arrives at week 7 out of nowhere is usually something else

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u/janoshik_junkieOPindependent tester53 points·5 months ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/ferritin_low230 points·5 months ago

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

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u/emil_barros92 points·5 months ago

if it is severe or persistent that is a clinician question, not a board question

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u/thermal_mass_tom64 points·5 months ago

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/plain_titration_2024108 points·5 months ago

Agreed on writing it down. I could not see the pattern until I had six weeks of it on one page.

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u/lina_dziedzic67 points·5 months ago

Which day of the week relative to the shot does it hit?

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u/nausea_notesside effects-11 points·5 months ago

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

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u/yannick_barros192 points·5 months ago

This. A bad fortnight after a step is expected. A bad quarter is a reason to talk to somebody who knows your history.

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u/blunt_coldbox_2024127 points·5 months ago

Severe, or unpleasant? They are genuinely different questions and the answers diverge.

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u/placebo_arm_pam94 points·5 months ago

Pushback: you changed the dose, the meal timing and the training in the same fortnight, so the attribution is guesswork.

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u/iman_castellanos79 points·5 months ago

fibre and water before you buy anything to fix it

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u/janoshik_junkieOPindependent tester32 points·5 months ago

Reflux was the one that got me. Stopped eating in the three hours before bed and it went from nightly to almost never.

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u/liv_okafor25 points·5 months ago

write down when it starts and stops, the pattern is the useful part

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u/coring_the_stopper63 points·5 months ago

reflux at night, try not eating in the three hours before bed

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u/sena_teixeira35 points·5 months ago

reflux at night, try not eating in the three hours before bed

Agreed, with the caveat that "usually settles" is not "always settles" and the exceptions should still get asked about properly.

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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