[Results] 49 weeks, 7kg, and dose escalation was the hard part
49 weeks, 7kg, and dose escalation was the hard part. Numbers below. Ask me the boring questions, they are the useful ones. Numbers, in the order they matter: 49 weeks and 7kg. Where the evidence actually stands, since every thread here assumes a different answer. Phase 2 reported a large mean body weight change at…
Yes — the comparison threads are apples to oranges and they generate more heat than anything else here.
Watched heart rate on a wearable across twelve weeks because the threads said to. It moved a little and I have no idea whether that means anything.
dose escalation in the trials was slow for a reason
Same read. The energy-expenditure mechanism is the interesting bit and it is not established in humans at scale.
dose escalation in the trials was slow for a reason
This is the sentence the rest of the board should read first. Phase 2 is not a label.
nothing here is available as a prescription product, so read every thread with that in mind
Disagree. "More receptors means more effect" is not how any of this works and the trial data does not support the linear story.