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c/retatrutide·submitted 3 months ago by u/nadia_norgaard

the glucagon thing finally clicked for me and I want to write it down

Trial Databranch of 7 comments

Thinking out loud about this: the glucagon thing finally clicked for me and I want to write it down. Read the phase 2 paper twice before ordering anything. Recommend that to anyone in this board: the error bars are the interesting part. Kept a log specifically because there is so little published. It is one person…

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This branch

7 comments, started 2 months ago
u/customs_seizure_sid26 points·2 months ago

The phase 2 readout ran to 48 weeks in a few hundred participants with a slow escalation. Both the size and the duration matter when people quote the headline number.

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u/renzo_yildiz8 points·2 months ago

heart rate is the thing people report watching

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u/crosspost_bot_no4 points·2 months ago

heart rate is the thing people report watching

Agreed, and the glucagon arm is exactly why the comparison threads do not work.

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u/nadia_norgaardOP0 points·2 months ago

What is the source for that figure — the published paper or a summary of it?

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u/lina_bruun1 point·2 months ago

Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use, and that is a statement of fact rather than a disclaimer.

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u/burned_once_twice1 point·2 months ago

Glucagon receptor agonism is associated with increased energy expenditure and with hepatic effects. That is a mechanistic story with strong preclinical support and limited phase 2 human data.

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u/deleted_my_history1 point·2 months ago

dose escalation in the trials was slow for a reason

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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